F1‐03‐04: Aβ‐POSITIVITY PREDICTS COGNITIVE DECLINE BUT COGNITION ALSO PREDICTS PROGRESSION TO Aβ‐POSITIVITY

Although the A/T/(N) framework is agnostic to the sequence of beta-amyloid (Aβ), p-tau, and neurodegeneration biomarkers, cognitive impairment is considered a consequence of the disease that appears late in the pathological process. However, changes in cognition may occur earlier than is commonly acknowledged. If the sequence of these processes is variable and overlapping, cognitive function and p-tau may predict progression from normal to...