Jeremy A. Elman
University of California, San Diego
Internal medicineOncologyPsychologyHeritabilityTwin studyNeuroscienceCognitionCognitive psychologyLocus coeruleusDiseaseDementiaMiddle ageCognitive declineCognitive impairmentAudiologyNeuroimagingClinical psychologyMedicineBiomarker (medicine)Episodic memoryVerbal fluency test
Publications 63
#1Nathan A. Gillespie (MCV: VCU Medical Center)H-Index: 35
#2Sean N. Hatton (University of California, Berkeley)H-Index: 22
Last. Ruth E. McKenzie (Merrimack College)H-Index: 2
view all 20 authors...
Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as Alzheimers Disease. Despite their increasing application, the genetic and environmental etiology of global PBA indices is unknown. Likewise, the degree to which genetic influences in PBA are longitudinally stable and how PBA changes over time are also unknown. We analyzed data from 734 men from the Vietnam Era Twin Study of Aging with repea...
#1Daniel E. Gustavson (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Amy J. Jak (Veterans Health Administration)H-Index: 38
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 10 authors...
Background null Although not strongly correlated with current objective cognitive ability, subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease. Most studies focus on SCD in relation to future decline rather than objective prior decline that it purportedly measures. null Objective null We evaluated whether self-report of cognitive decline-as a continuous measure-corresponds to objectively-assessed episodic memory and executive function decline across the same period. null ...
#1McKenna E. Williams (UCSD: University of California, San Diego)H-Index: 1
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. Nathan A. Gillespie (VCU: Virginia Commonwealth University)H-Index: 35
view all 27 authors...
#1Anders M. Fjell (University of Oslo)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta HåbergH-Index: 43
view all 24 authors...
Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 lo...
#1Bethlehem Ra (University of Cambridge)H-Index: 2
#2Jakob Seidlitz (UPenn: University of Pennsylvania)H-Index: 19
Last. Areces-Gonzalez A (University of Electronic Science and Technology of China)
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Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource ( to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study,...
1 CitationsSource
#1Anders M. Fjell (Oslo University Hospital)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta Håberg (NTNU: Norwegian University of Science and Technology)H-Index: 43
view all 24 authors...
#1Tyler Bell (UCSD: University of California, San Diego)H-Index: 9
Last. William S. KremenH-Index: 70
view all 5 authors...
#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 18 authors...
Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 30 authors...
INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
1 CitationsSource
#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 85
view all 27 authors...
Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource