Matthew S. Panizzon
University of California, San Diego
Internal medicineEndocrinologyDevelopmental psychologyDemographyPsychologyHeritabilityTwin studyNeuroscienceCognitionYoung adultDiseaseMiddle ageCerebral cortexCognitive impairmentAudiologyGenetic variationClinical psychologyGenetic correlationMedicineBiologyEpisodic memory
Publications 175
#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
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ABSTRACT null null We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. During VETSA, MRI-based measures at mean age 68 included predicted b...
#1Nathan A. Gillespie (MCV: VCU Medical Center)H-Index: 35
#2Sean N. Hatton (University of California, Berkeley)H-Index: 22
Last. Ruth E. McKenzie (Merrimack College)H-Index: 2
view all 20 authors...
Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as Alzheimers Disease. Despite their increasing application, the genetic and environmental etiology of global PBA indices is unknown. Likewise, the degree to which genetic influences in PBA are longitudinally stable and how PBA changes over time are also unknown. We analyzed data from 734 men from the Vietnam Era Twin Study of Aging with repea...
#1Ursula G. Saelzler (UCSD: University of California, San Diego)
#2Paul Verhaeghen (Georgia Institute of Technology)H-Index: 35
Last. Scott D. Moffat (Georgia Institute of Technology)H-Index: 31
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Hypersecretion of the glucocorticoid steroid hormone cortisol by individuals with Alzheimer's disease (AD) has been suspected for several decades, during which time dozens of examinations of this phenomenon have been conducted and published. The goals of this investigation were to summarize this sizeable body of literature, test whether participant and methodological characteristics modify the magnitude of the AD-associated basal cortisol hypersecretion, and examine whether cortisol circadian rh...
#1Daniel E. Gustavson (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Amy J. Jak (Veterans Health Administration)H-Index: 38
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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Background null Although not strongly correlated with current objective cognitive ability, subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease. Most studies focus on SCD in relation to future decline rather than objective prior decline that it purportedly measures. null Objective null We evaluated whether self-report of cognitive decline-as a continuous measure-corresponds to objectively-assessed episodic memory and executive function decline across the same period. null ...
#1McKenna E. Williams (UCSD: University of California, San Diego)H-Index: 1
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. Nathan A. Gillespie (VCU: Virginia Commonwealth University)H-Index: 35
view all 27 authors...
#1Anders M. Fjell (University of Oslo)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta HåbergH-Index: 43
view all 24 authors...
Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 lo...
#1Jennifer A. Sumner (UCLA: University of California, Los Angeles)H-Index: 27
#2Adam X. Maihofer (UCSD: University of California, San Diego)H-Index: 22
Last. Bekh Bradley (Emory University)H-Index: 66
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Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Heal...
#1Marianna Gasperi (UCSD: University of California, San Diego)H-Index: 4
#2Niloofar Afari (Veterans Health Administration)H-Index: 34
Last. Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
view all 5 authors...
Chronic pain and post-traumatic stress disorder (PTSD) frequently co-occur, and research suggests that these two conditions exacerbate one another producing greater impact on normal functioning in combination than separately. The influence of traumatic experiences on both pain and PTSD have been shown, but the nature of this interplay remains unclear. Although Criterion A trauma is required for the diagnosis of PTSD, whether the association between PTSD and chronic pain is dependent on Criterion...
#1Anders M. Fjell (Oslo University Hospital)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta Håberg (NTNU: Norwegian University of Science and Technology)H-Index: 43
view all 24 authors...
#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 18 authors...
Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...