William S. Kremen
Veterans Health Administration
PsychiatryInternal medicineDevelopmental psychologyNeuropsychologyDemographyPsychologyHeritabilityTwin studyNeuroscienceCognitionYoung adultWorking memoryDiseasePsychosisMiddle ageGeneticsAudiologyClinical psychologyMedicineSchizophreniaBiology
Publications 346
#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
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ABSTRACT null null We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. During VETSA, MRI-based measures at mean age 68 included predicted b...
#1Nathan A. Gillespie (MCV: VCU Medical Center)H-Index: 35
#2Sean N. Hatton (University of California, Berkeley)H-Index: 22
Last. Ruth E. McKenzie (Merrimack College)H-Index: 2
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Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as Alzheimers Disease. Despite their increasing application, the genetic and environmental etiology of global PBA indices is unknown. Likewise, the degree to which genetic influences in PBA are longitudinally stable and how PBA changes over time are also unknown. We analyzed data from 734 men from the Vietnam Era Twin Study of Aging with repea...
#1Daniel E. Gustavson (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Amy J. Jak (Veterans Health Administration)H-Index: 38
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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Background null Although not strongly correlated with current objective cognitive ability, subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease. Most studies focus on SCD in relation to future decline rather than objective prior decline that it purportedly measures. null Objective null We evaluated whether self-report of cognitive decline-as a continuous measure-corresponds to objectively-assessed episodic memory and executive function decline across the same period. null ...
#1McKenna E. Williams (UCSD: University of California, San Diego)H-Index: 1
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. Nathan A. Gillespie (VCU: Virginia Commonwealth University)H-Index: 35
view all 27 authors...
#1Anders M. Fjell (University of Oslo)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta HåbergH-Index: 43
view all 24 authors...
Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 lo...
#1Jennifer A. Sumner (UCLA: University of California, Los Angeles)H-Index: 27
#2Adam X. Maihofer (UCSD: University of California, San Diego)H-Index: 22
Last. Bekh Bradley (Emory University)H-Index: 66
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Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Heal...
#1Bethlehem Ra (University of Cambridge)H-Index: 2
#2Jakob Seidlitz (UPenn: University of Pennsylvania)H-Index: 19
Last. Areces-Gonzalez A (University of Electronic Science and Technology of China)
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Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource (www.brainchart.io) to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study,...
1 CitationsSource
#1Anders M. Fjell (Oslo University Hospital)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta Håberg (NTNU: Norwegian University of Science and Technology)H-Index: 43
view all 24 authors...
#1Tyler Bell (UCSD: University of California, San Diego)H-Index: 9
Last. William S. KremenH-Index: 70
view all 5 authors...
#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 18 authors...
Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...