William S. Kremen
University of California, Berkeley
PsychiatryInternal medicineDevelopmental psychologyNeuropsychologyDemographyPsychologyHeritabilityTwin studyNeuroscienceCognitionYoung adultDiseasePsychosisMiddle ageGeneticsAudiologyGenetic variationClinical psychologyMedicineSchizophreniaBiology
471Publications
71H-index
15.6kCitations
Publications 342
Newest
#2Jeremy A. ElmanH-Index: 15
Last. William S. KremenH-Index: 71
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#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 18 authors...
Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...
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#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
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INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
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#1Daniel E. Gustavson (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
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Despite the relevance of semantic fluency measures to risk for dementia and psychiatric disorders, little is known about their genetic and environmental architecture in mid-to-late life. Participants represent 21,684 middle-aged and older adult twins (M = 60.84 years, SD = 11.21; Range 40-89) from six studies from three countries participating in the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium. All completed the same measure of semantic fluency (naming animals i...
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#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 86
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Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource
#1David F. Tate (UofU: University of Utah)H-Index: 4
#1David F. Tate (UofU: University of Utah)H-Index: 50
Last. Elisabeth A. Wilde (BCM: Baylor College of Medicine)H-Index: 53
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Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a characteristic abnormal central neurologic area(s) of abnormality pathognomonic to the disorder, a sufficient head impact may cause focal, multifocal, diffuse or combination of injury to the brain. This inconsistent presentation makes it difficul...
2 CitationsSource
#1Riki E Slayday (SDSU: San Diego State University)
#2Daniel E. Gustavson (UCSD: University of California, San Diego)H-Index: 16
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
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OBJECTIVE Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) e4 allele, a risk factor for Alzheimer's disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would sho...
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#1Burcu F. Darst (UW: University of Wisconsin-Madison)H-Index: 17
#2Zhiguang Huo (UF: University of Florida)H-Index: 12
Last. Corinne D. Engelman (UW: University of Wisconsin-Madison)H-Index: 28
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BACKGROUND Understanding metabolic mechanisms associated with cognitive changes preceding an Alzheimer's disease (AD) diagnosis could advance our understanding of AD progression and inform preventive methods. OBJECTIVE We investigated the metabolomics of the early changes in executive function and delayed recall, the earliest aspects of cognitive function to change in the course of AD development, in order to better understand mechanisms that could contribute to early stages and progression of t...
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#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
#2T. Warren (SDSU: San Diego State University)
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
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#1T. Warren (SDSU: San Diego State University)
#2Shandell Pahlen (UCR: University of California, Riverside)H-Index: 10
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
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