Alzheimers & Dementia
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#1Ana Belen Lopez-Rodriguez (Trinity College, Dublin)H-Index: 13
#2Edel Hennessy (Trinity College, Dublin)H-Index: 11
Last. Colm Cunningham (Trinity College, Dublin)H-Index: 53
view all 16 authors...
Neuroinflammation contributes to Alzheimer's disease (AD) progression. Secondary inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular contributors to this vulnerability require elucidation. Using APP/PS1 mice and AD brain, we studied secondary inflammatory insults to investigate hypersensitive responses in microglia, astrocytes, neurons, and human brain tissue. The NLRP3 inflammasome was assembled surrounding amyloid beta, and microglia were primed, fac...
#1Nicolai Franzmeier (LMU: Ludwig Maximilian University of Munich)H-Index: 18
#2Rik Ossenkoppele (Lund University)H-Index: 42
view all 14 authors...
INTRODUCTION The BIN1 rs744373 single nucleotide polymorphism (SNP) is a key genetic risk locus for Alzheimer's disease (AD) associated with tau pathology. Because tau typically accumulates in response to amyloid beta (Aβ), we tested whether BIN1 rs744373 accelerates Aβ-related tau accumulation. METHODS We included two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI], n = 153; Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably [BioFINDER], n = 63) with longitudi...
#1Patricia A. Boyle (Rush University Medical Center)H-Index: 86
#2Tianhao Wang (Rush University Medical Center)H-Index: 16
Last. David A. Bennett (Rush University Medical Center)H-Index: 180
view all 11 authors...
INTRODUCTION We identified a "cognitive clock," a novel indicator of brain health that provides person-specific estimates of cognitive age, and tested the hypothesis that cognitive age is a better predictor of brain health than chronological age in two independent datasets. METHODS The initial analyses were based on 1057 participants from the Rush Memory and Aging Project and the Religious Orders Study who began without impairment and underwent cognitive assessments up to 24 years. A shape invar...
#1Claire E. Sexton (Alzheimer's Association)
#2Kaarin J. Anstey (UNSW: University of New South Wales)H-Index: 89
Last. Maria C. Carrillo (Alzheimer's Association)H-Index: 60
view all 35 authors...
The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal ...
#1Noemí Esteras (UCL Institute of Neurology)H-Index: 13
#2Olga Kopach (UCL Institute of Neurology)H-Index: 12
Last. Andrey Y. Abramov (UCL Institute of Neurology)H-Index: 72
view all 10 authors...
INTRODUCTION The second most common form of early-onset dementia-frontotemporal dementia (FTD)-is often characterized by the aggregation of the microtubule-associated protein tau. Here we studied the mechanism of tau-induced neuronal dysfunction in neurons with the FTD-related 10+16 MAPT mutation. METHODS Live imaging, electrophysiology, and redox proteomics were used in 10+16 induced pluripotent stem cell-derived neurons and a model of tau spreading in primary cultures. RESULTS Overproduction o...
#1Edo Richard (Radboud University Nijmegen)H-Index: 32
#2Melina G H E den Brok (Radboud University Nijmegen)
Last. Willem A. van Gool (UvA: University of Amsterdam)H-Index: 42
view all 3 authors...
Numerous clinical trials of anti-amyloid beta (Aβ) immunotherapy in Alzheimer's disease have been performed. None of these have provided convincing evidence for beneficial effects. Using traditional frequentist meta-analysis, the conclusion is that there is absence of evidence for a therapeutic effect, with a point estimate effect size of 0.05 (95% confidence interval -0.00 to 0.10, P = .055). In addition, this non-significant effect equates to 0.4 points per year on the cognitive subscale of th...
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#1Abolfazl Avan (MUMS: Mashhad University of Medical Sciences)H-Index: 8
#2Vladimir Hachinski (UWO: University of Western Ontario)H-Index: 109
INTRODUCTION Stroke and dementia share a number of modifiable risk factors and are the leading cause of neurological disability and death worldwide. METHODS We report the 2019 estimations for global disability-adjusted life years (DALYs) and death numbers and rates related to stroke and dementia, as well as their risk attributed DALYs and deaths and their changes between 2010 and 2019. RESULTS Stroke accounted for 69.8%, dementia for 17.3%, and combined contributed to 87.2% (8.2 million) of neur...
#1Sid E. O'Bryant (University of North Texas Health Science Center)H-Index: 39
#2Fan Zhang (University of North Texas Health Science Center)H-Index: 13
Last. Hable Study Team (University of North Texas Health Science Center)
view all 14 authors...
INTRODUCTION Representation of Mexican Americans in Alzheimer's disease (AD) clinical research has been extremely poor. METHODS Data were examined from the ongoing community-based, multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Participants underwent functional exams, clinical labs, neuropsychological testing, and 3T magnetic resonance imaging of the brain. Fasting proteomic markers were examined for predicting mild cognitive impairment (MCI) and AD using support vector mac...
#1David W. Nauen (Johns Hopkins University)H-Index: 13
#2Juan C. Troncoso (Johns Hopkins University)H-Index: 107
Degradation and clearance of amyloid beta (Aβ) peptide are likely critical for brain health. Animal studies have demonstrated the role of the glial-lymphatic (glymphatic) system in the clearance of Aβ and other brain metabolites, but no such information has been available in humans. Here we ask whether this system contributes to the clearance of Aβ from the human brain. In the absence of an applicable imaging method, we examined cervical and inguinal lymph nodes resected for cancer therapy or st...
#1Zvinka Z. Zlatar (UCSD: University of California, San Diego)H-Index: 15
#2Wassim Tarraf (WSU: Wayne State University)H-Index: 19
Last. Hector M. González (UCSD: University of California, San Diego)H-Index: 31
view all 14 authors...
INTRODUCTION Despite increased risk of cognitive decline in Hispanics/Latinos, research on early risk markers of Alzheimer's disease in this group is lacking. Subjective cognitive decline (SCD) may be an early risk marker of pathological aging. We investigated associations of SCD with objective cognition among a diverse sample of Hispanics/Latinos living in the United States. METHODS SCD was measured with the Everyday Cognition Short Form (ECog-12) and cognitive performance with a standardized b...
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