Alzheimers & Dementia
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#1Julia Burgdorf (Johns Hopkins University)H-Index: 4
#2Halima Amjad (Johns Hopkins University)H-Index: 4
Last. Kathryn H. Bowles (UPenn: University of Pennsylvania)H-Index: 31
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BACKGROUND In Medicare-funded home health care (HHC), one in three patients has cognitive impairment (CI), but little is known about the care intensity they receive in this setting. Recent HHC reimbursement changes fail to adjust for patient CI, potentially creating a financial disincentive to caring for these individuals. METHODS This cohort study included a nationally representative sample of 1214 Medicare HHC patients between 2011 and 2016. Multivariable logistic and negative binomial regress...
#1Andrea Du Preez ('KCL': King's College London)H-Index: 4
#2Sophie Lefèvre-Arbogast (University of Bordeaux)H-Index: 5
Last. Mercè Pallàs (University of Barcelona)H-Index: 60
view all 22 authors...
Introduction null Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia. null Methods null Using an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their associatio...
#1Cunwei Sun (GLMU: Guilin Medical University)
#2Yanhua Xiao (GLMU: Guilin Medical University)
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Dipeptidyl peptidase-4 (DPP4) has been proven to exert its functions by both enzymatic and nonenzymatic pathways. The nonenzymatic function of DPP4 in diabetes-associated cognitive impairment remains unexplored. We determined DPP4 protein concentrations or its enzymatic activity in type 2 diabetic patients and db/db mice and tested the impact of the non-enzymatic function of DPP4 on mitochondrial dysfunction and cognitive impairment both in vivo and in vitro. The results show that increased DPP4...
#1Armineh L Ghazarian (NIH: National Institutes of Health)
#2Todd Haim (NIH: National Institutes of Health)
Last. Pragati Katiyar (NIH: National Institutes of Health)
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Introduction null The National Institute on Aging (NIA) provides funding to academic researchers and small businesses working in the Alzheimer's Disease (AD) and AD-related dementia (ADRD) fields to help commercialize their products. The NIA uses Small Business Innovation Research (SBIR) awards to bridge the funding gap in the diagnostic, therapeutic, and care interventions areas, enabling startups to reach key value inflection points to achieve scientific milestones. null Methods null Only publ...
#1Andrew Peterson (UPenn: University of Pennsylvania)
#2Justin T. Clapp (UPenn: University of Pennsylvania)H-Index: 10
Last. Jason Karlawish (UPenn: University of Pennsylvania)H-Index: 69
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Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A provisional definition was proposed by the 2018 National Institute on Aging expert workshop and published in Alzheimer's and Dementia. However, several conceptual features of this definition remain vague, creating barriers to robust clinical research. Here, we critically analyze the provisional definition and present a refined definition that can be applied in clinical research. The refined definition is ...
#1Karolina G. César-Freitas (USP: University of São Paulo)
#2Claudia K. Suemoto (USP: University of São Paulo)H-Index: 22
Last. Ricardo Nitrini (USP: University of São Paulo)H-Index: 56
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INTRODUCTION Few dementia incidence studies have been performed in Latin America. We aimed to provide the incidence of dementia in a Brazilian community-dwelling elderly population. METHODS This study was conducted in urban and rural areas of Tremembe. The 520 participants without dementia at baseline were invited to participate in the follow-up. RESULTS After a median follow-up of 5 years, the incidence rate of dementia was 26.1 per 1000 person-years (PY) (95% confidence interval = 18.7-36.6/10...
#1Joni V Lindbohm (UH: University of Helsinki)H-Index: 10
#1Joni V Lindbohm (UH: University of Helsinki)H-Index: 2
Last. Ruth C. Lovering (UCL: University College London)H-Index: 40
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Introduction null Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20-year follow-ups. null Methods null In the Whitehall II prospective cohort study proteins were measured using SOMAscan technology. Cognitive performance was tested five times over 20 years...
#1Barbara Borroni (University of Brescia)H-Index: 69
#2Caroline Graff (Karolinska University Hospital)H-Index: 54
Last. Harro Seelaar (Erasmus University Medical Center)H-Index: 24
view all 14 authors...
Introduction null The incidence of Frontotemporal Lobar Degeneration (FTLD)-related disorders and their characteristics are not well known. The "FRONTotemporal dementia Incidence European Research Study" (FRONTIERS) is designed to fill this gap. null Methods null FRONTIERS is a European prospective, observational population study based on multinational registries. FRONTIERS comprises 11 tertiary referral centers across Europe with long-lasting experience in FTLD-related disorders and comprehensi...
#2Lina MørchH-Index: 1
Last. Amani Meaidi (UCPH: University of Copenhagen)H-Index: 3
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Introduction null Use of systemic hormone therapy has been positively associated with development of dementia. Little is known about the dose-dependent effect of vaginal estradiol on dementia risk. null Methods null We assessed associations between cumulative dose of vaginal estradiol tablets and dementia in a case-control study nested in a nationwide Danish cohort of women aged 50 to 60 years at study initiation, who did not use systemic hormone therapy. Each case was age-matched to 10 female c...
#1Antoine Garnier-Crussard (University of Lyon)
#2Salma Bougacha (UNICAEN: University of Caen Lower Normandy)H-Index: 1
Last. Denis Vivien (UNICAEN: University of Caen Lower Normandy)H-Index: 66
view all 12 authors...
Introduction null White matter hyperintensities (WMH) are often described in Alzheimer's disease (AD), but their topography and specific relationships with cognition remain unclear. null Methods null Regional WMH were estimated in 54 cognitively impaired amyloid beta-positive AD (Aβpos-AD), compared to 40 cognitively unimpaired amyloid beta-negative older controls (Aβneg-controls) matched for vascular risk factors. The cross-sectional association between regional WMH volume and cognition was ass...
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Diabetes mellitus