Alzheimers & Dementia
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#1Longfei Jia (Capital Medical University)H-Index: 17
#2Min Zhu (Capital Medical University)H-Index: 2
Last. Jianping Jia (Capital Medical University)H-Index: 36
view all 16 authors...
Introduction Exosomes are an emerging candidate for biomarkers of Alzheimer's disease (AD). This study investigated whether exosomal synaptic proteins can predict AD at the asymptomatic stage. Methods We conducted a two-stage-sectional study (discovery stage: AD, 28; amnestic mild cognitive impairment [aMCI], 25; controls, 29; validation stage: AD, 73; aMCI, 71; controls, 72), a study including preclinical AD (160) and controls (160), and a confirmation study in familial AD (mutation carriers: 5...
6 CitationsSource
#1Peter J. Snyder (URI: University of Rhode Island)H-Index: 6
#2Jessica Alber (URI: University of Rhode Island)H-Index: 7
Last. Heather M. Snyder (Alzheimer's Association)H-Index: 15
view all 19 authors...
In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying ...
3 CitationsSource
#1Annalisa ChiariH-Index: 7
#2Giulia VincetiH-Index: 3
Last. Marco Vinceti (BU: Boston University)H-Index: 42
view all 11 authors...
INTRODUCTION Patients with early onset dementia (EOD), defined as dementia with symptom onset at age <65, frequently present with atypical syndromes. However, the epidemiology of different EOD presentations, including variants of Alzheimer's disease (AD) and frontotemporal dementia (FTD), has never been investigated all together in a population-based study. Epidemiologic data of all-cause EOD are also scarce. METHODS We investigated EOD epidemiology by identifying patients with EOD seen in the e...
2 CitationsSource
#1Mohamad Habes (UPenn: University of Pennsylvania)H-Index: 16
#1Mohamad HabesH-Index: 2
Last. Christos Davatzikos (UPenn: University of Pennsylvania)H-Index: 90
view all 29 authors...
Introduction Relationships between brain atrophy patterns of typical aging and Alzheimer's disease (AD), white matter disease, cognition, and AD neuropathology were investigated via machine learning in a large harmonized magnetic resonance imaging database (11 studies; 10,216 subjects). Methods Three brain signatures were calculated: Brain-age, AD-like neurodegeneration, and white matter hyperintensities (WMHs). Brain Charts measured and displayed the relationships of these signatures to cogniti...
1 CitationsSource
#1Justina F. Avila (UNM: University of New Mexico)H-Index: 6
#2Miguel Arce Rentería (Columbia University)H-Index: 3
Last. Jennifer J. Manly (Columbia University)H-Index: 67
view all 27 authors...
Introduction We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. Methods A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter...
2 CitationsSource
#1Michael R. Dueñas (American Optometric Association)H-Index: 1
#2Peter J. Snyder (URI: University of Rhode Island)H-Index: 6
There exists a public health imperative to discover and to develop disease-modifying Alzheimer's disease (AD) therapeutics to protect the health of millions of individuals facing AD. Achievement of this goal will be dependent on developing the clinical tools to detect high risk, in the earliest phases of the disease, and at the population level. This article describes the study of retinal biomarkers for the identification of, and tracking of change over time for, individuals in the preclinical s...
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#1Amy F.T. Arnsten (Yale University)H-Index: 75
#2Dibyadeep Datta (Yale University)H-Index: 11
Last. Heiko Braak (University of Ulm)H-Index: 102
view all 4 authors...
The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We hypothesize that tau pathology within select projection neurons with susceptible microenvironments can initiate sAD. This postulate rests on extensive data demonstrating that in human brains tau pathology appears about a decade before the formation of Aβ plaques (Aβps), especially targeting glutamate projection neurons in the association cortex. Data from aging rhesus monkeys show abnormal tau phosphorylation w...
4 CitationsSource
#1Johanna Thunell (SC: University of Southern California)H-Index: 2
#2Yi Chen (SC: University of Southern California)H-Index: 1
Last. Julie Zissimopoulos (SC: University of Southern California)H-Index: 20
view all 7 authors...
INTRODUCTION Most older Americans use drug therapies for chronic conditions. Several are associated with risk of Alzheimer's disease and related dementias (ADRD). METHODS A scoping review was used to identify drug classes associated with increasing or decreasing ADRD risk. We analyzed size, type, and findings of the evidence. RESULTS We identified 29 drug classes across 11 therapeutic areas, and 404 human studies. Most common were studies on drugs for hypertension (93) or hyperlipidemia (81). Fe...
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#1Eric D. Vidoni (KU: University of Kansas)H-Index: 26
#2In-Young ChoiH-Index: 25
Last. Russell H. SwerdlowH-Index: 61
view all 18 authors...
INTRODUCTION Brain bioenergetics are defective in Alzheimer's disease (AD). Preclinical studies find oxaloacetate (OAA) enhances bioenergetics, but human safety and target engagement data are lacking. METHODS We orally administered 500 or 1000 mg OAA, twice daily for 1 month, to AD participants (n = 15 each group) and monitored safety and tolerability. To assess brain metabolism engagement, we performed fluorodeoxyglucose positron emission tomography (FDG PET) and magnetic resonance spectroscopy...
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#1Yanfeng Jiang (Fudan University)H-Index: 8
#2Mei Cui (Fudan University)H-Index: 16
Last. Xingdong Chen (Fudan University)H-Index: 14
view all 15 authors...
China has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under-researched. Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is crucial to build appropriate infrastructure for long-term longitudinal studies to advance Chinese cognitive aging and dementia research. We initiated a community-based prospective cohort-the Ta...
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