Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment
Abstract
Understanding genetic influences on Alzheimer's disease (AD) may improve early identification. AD polygenic risk scores (AD-PRSs) are associated with increased odds of AD and mild cognitive impairment (MCI). Additional sources of genetic risk may also contribute to disease outcomes. Coronary artery disease (CAD) is a risk factor for AD, interacts with AD pathology, and is also heritable. We showed that incidence-based and prevalence-based...
Paper Details
Title
Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment
Published Date
Dec 1, 2019
Journal
Volume
84
Pages
237.e5 - 237.e12
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