Anders M. Dale
University of California, San Diego
Genome-wide association studyInternal medicinePathologyMagnetic resonance imagingDiffusion MRISingle-nucleotide polymorphismArtificial intelligencePsychologyNeuroscienceCognitionGenetic associationDiseaseCerebral cortexWhite matterComputer scienceBrain mappingGeneticsNeuroimagingMedicineBiology
Publications 847
#1Shahram Bahrami (Oslo University Hospital)H-Index: 9
#2Kaja Nordengen (Oslo University Hospital)
Last. Tobias Kaufmann (Oslo University Hospital)H-Index: 35
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Despite its major role in complex human behaviours across the lifespan, including memory formation and decline, navigation and emotions, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 individuals, we revealed 173 unique genetic loci with distributed associations across the hippocampal formation. We identified profound genetic overlap with eight major developmental an...
#1R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
#2Jonathan Ahern (UCSD: University of California, San Diego)
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder that can lead to iron overload, causing oxidative damage to affected organs. HH type 1 is predominantly associated with homozygosity for the mutation p.C282Y. Previous case studies have reported tentative links between HH and movement disorders, e.g., Parkinson9s disease, and basal ganglia abnormalities on magnetic resonance imaging. We investigated the impact of p.C282Y homozygosity: on whole brain T2 intensity differenc...
#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
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ABSTRACT null null We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. During VETSA, MRI-based measures at mean age 68 included predicted b...
#1Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 10
#2Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 15
Last. Artitaya Lophatananon (University of Manchester)H-Index: 31
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Introduction: Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets. Methods: In total, 299 SNPs previously associated with prostate canc...
#1Nathan A. Gillespie (MCV: VCU Medical Center)H-Index: 35
#2Sean N. Hatton (University of California, Berkeley)H-Index: 22
Last. Ruth E. McKenzie (Merrimack College)H-Index: 2
view all 20 authors...
Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as Alzheimers Disease. Despite their increasing application, the genetic and environmental etiology of global PBA indices is unknown. Likewise, the degree to which genetic influences in PBA are longitudinally stable and how PBA changes over time are also unknown. We analyzed data from 734 men from the Vietnam Era Twin Study of Aging with repea...
#1Linn Rødevand (Oslo University Hospital)H-Index: 6
#2Shahram Bahrami (Oslo University Hospital)H-Index: 9
Last. Srdjan Djurovic (University of Bergen)H-Index: 77
view all 14 authors...
Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic overlap between BIP and CVD phenotypes, including CVD risk factors and coronary artery disease (CAD). We analyzed large genome-wide association studies of BIP (n = 51,710) and CVD phenotypes (n = 159,208-795,640), using bivariate causal mixture model (MiXeR), which estimate...
#1Guy Hindley ('KCL': King's College London)H-Index: 4
#2Kevin O'Connell (Oslo University Hospital)H-Index: 12
Last. Aihua Lin (Oslo University Hospital)H-Index: 1
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Mood instability (MOOD) is a transdiagnostic phenomenon with a prominent neurobiological basis. Recent genome-wide association studies found significant positive genetic correlation between MOOD and major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap between MOOD and psychiatric disorders beyond genetic correlation to better characterize putative shared genetic determinants. Summary statistics for schizophrenia (SCZ, n=105,318), bi...
#1Shahram Bahrami (Oslo University Hospital)H-Index: 9
#2Guy Hindley (Oslo University Hospital)H-Index: 4
Last. Ketil Joachim Ødegaard (Haukeland University Hospital)H-Index: 3
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Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five shared risk loci. Using the largest samples to date and novel statistical tools, we aimed to determi...
#1Kevin O'Connell (Oslo University Hospital)H-Index: 12
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Alexey A. Shadrin (Oslo University Hospital)H-Index: 12
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ABSTRACT null null Background null A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here we applied novel statistical genetic methodologies to better characterize the potential shared genetic architecture between sleep-related phenotypes and psychiatric disorders. null null null Methods null Utilizing the MiXeR method, that can estimate polygenic o...
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 11 authors...
The molecular determinants of tissue composition of the human brain remain largely unknown. Recent genome-wide association studies (GWAS) on this topic have had limited success due to methodological constraints. Here, we apply advanced whole-brain analyses on multi-shell diffusion imaging data and multivariate GWAS to two large scale imaging genetic datasets (UK Biobank and the Adolescent Brain Cognitive Development study) to identify and validate genetic association signals. We discovered 503 u...