Anders M. Dale
University of California, San Diego
Genome-wide association studyInternal medicinePathologyMagnetic resonance imagingDiffusion MRISingle-nucleotide polymorphismArtificial intelligencePsychologyNeuroscienceCognitionGenetic associationDiseaseCerebral cortexWhite matterComputer scienceBrain mappingGeneticsNeuroimagingMedicineBiology
Publications 841
Last. Tyler M. SeibertH-Index: 16
view all 16 authors...
PurposeMultiparametric MRI (mpMRI) improves detection of clinically significant prostate cancer (csPCa), but the qualitative PI-RADS system and quantitative apparent diffusion coefficient (ADC) yield inconsistent results. An advanced Restrictrion Spectrum Imaging (RSI) model may yield a better quantitative marker for csPCa, the RSI restriction score (RSIrs). We evaluated RSIrs for patient-level detection of csPCa. Materials and MethodsRetrospective analysis of men who underwent mpMRI with RSI an...
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 55
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by secondary and independ...
1 CitationsSource
#1Niamh Mullins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 17
#2Andreas J. Forstner (University of Marburg)H-Index: 5
Last. Ole A. Andreassen (University of Oslo)H-Index: 125
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Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in ge...
2 CitationsSource
#1Dennis van der MeerH-Index: 20
#2Alexey A. ShadrinH-Index: 11
Last. Tobias KaufmannH-Index: 33
view all 17 authors...
#1Yi Li (UCSF: University of California, San Francisco)H-Index: 94
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 71
Last. Sandra A. Brown (UCSD: University of California, San Diego)H-Index: 124
view all 109 authors...
Importance Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to findings requiring urgent medical intervention. In the case of brain magnetic resonance imaging (MRI), reliable data about the prevalence and significance of IFs in the general population are limited, making it difficult to anticipate, communicate, and manage these findings. Objectives To determine the overall prevalence of IFs in brain MRI in the nonclinical...
#2Alexey A. ShadrinH-Index: 11
Last. Anders M. DaleH-Index: 165
view all 12 authors...
Genome-Wide Association studies have typically been limited to single phenotypes, given that high dimensional phenotypes incur a large multiple comparisons burden: ~1 million tests across the genome times the number of phenotypes. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement in power t...
#1Clare E. Palmer (UCSD: University of California, San Diego)H-Index: 10
#2Weiqi Zhao (UCSD: University of California, San Diego)H-Index: 5
Last. Terry L. JerniganH-Index: 101
view all 8 authors...
Cognitive performance in children is predictive of academic and social outcomes; therefore, understanding neurobiological mechanisms underlying individual differences in cognition during development may be important for improving quality of life. The belief that a single, psychological construct underlies many cognitive processes is pervasive throughout society. However, it is unclear if there is a consistent neural substrate underlying many cognitive processes. Here, we show that a distributed ...
#1Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
#2Christopher C. Conlin (UCSD: University of California, San Diego)H-Index: 3
Last. Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 16
view all 11 authors...
BACKGROUND Diffusion magnetic resonance imaging (MRI) is integral to detection of prostate cancer (PCa), but conventional apparent diffusion coefficient (ADC) cannot capture the complexity of prostate tissues and tends to yield noisy images that do not distinctly highlight cancer. A four-compartment restriction spectrum imaging (RSI4 ) model was recently found to optimally characterize pelvic diffusion signals, and the model coefficient for the slowest diffusion compartment, RSI4 -C1 , yielded g...
1 CitationsSource
#1Dominic Holland (UCSD: University of California, San Diego)H-Index: 49
#2Oleksandr Frei (University of Oslo)H-Index: 18
Last. Anders M. Dale (UCSF: University of California, San Francisco)H-Index: 2
view all 8 authors...
We propose an extended Gaussian mixture model for the distribution of causal effects of common single nucleotide polymorphisms (SNPs) for human complex phenotypes that depends on linkage disequilibrium (LD) and heterozygosity (H), while also allowing for independent components for small and large effects. Using a precise methodology showing how genome-wide association studies (GWASs) summary statistics (z-scores) arise through LD with underlying causal SNPs, we applied the model to GWAS of multi...
#1Robert John Loughnan (University of California, Berkeley)H-Index: 3
#2Clare E. Palmer (University of California, Berkeley)H-Index: 10
Last. Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
view all 7 authors...
Background: Findings in adults have shown more culturally sensitive 9crystallized9 measures of intelligence have greater heritability, these results were not able to be shown in children. Methods: With data from 8,518 participants, aged 9 to 11, from the Adolescent Brain Cognitive Development (ABCD) Study®, we used polygenic predictors of intelligence test performance (based on genome-wide association meta-analyses of data from 269,867 individuals) and of educational attainment (based on data fr...
3 CitationsSource