Neurobiology of Aging
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#1Ryan A. Mace (Suffolk University)H-Index: 9
#2David A. Gansler (Suffolk University)H-Index: 20
Last. Michael K. Suvak (Suffolk University)H-Index: 35
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Abstract Growing evidence has linked cardiorespiratory fitness (CRF) to more conserved white matter (WM) microstructure. Additional research is needed to determine which WM tracts are most strongly related to CRF and if the neuroprotective effects of CRF are age-dependent. Participants were community-dwelling adults (N = 499; ages 20-85) from the open-access Nathan Kline Institute – Rockland Sample (NKI-RS) with CRF (bike test) and diffusion tensor imaging (DTI) data. Mixed-effect modeling teste...
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#1Antonella Caccamoa Ramona Belfiore (ASU: Arizona State University)
#2Salvatore Oddo (ASU: Arizona State University)H-Index: 63
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#1Matthew L. Russo (Rush University Medical Center)H-Index: 1
#2Elizabeth Molina-Campos (Rush University Medical Center)H-Index: 2
Last. Gabriel Carballo (Rush University Medical Center)H-Index: 1
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Abstract 1 null null null The hippocampus is vulnerable to deterioration in Alzheimer's disease (AD). It is, however, a heterogeneous structure, which may contribute to the differential volumetric changes along its septotemporal axis during AD progression. Here, we investigated amyloid plaque deposition along the dorsoventral axis in two strains of transgenic AD (ADTg) mouse models. We also used patch-clamp physiology in these mice to probe for functional consequences of AD pathogenesis in ventr...
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#1Joshua Young (NTU: Nottingham Trent University)
#2Emily Gallagher (NTU: Nottingham Trent University)
Last. Keeley J. Brookes (NTU: Nottingham Trent University)H-Index: 26
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Abstract null null The Brains for Dementia Research (BDR) cohort (~3200) is a longitudinal clinicopathological programme, complimented with genetic analysis for the purposes of aetiological investigation into dementia. Here the data from genetic association analyses are presented from the initial collection of DNA from the BDR cohort. The aim of this study was to investigate the preliminary association signals for pathologically confirmed Alzheimer's disease samples compared to controls with no ...
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#1Joyce van Arendonk (EUR: Erasmus University Rotterdam)
#2Pinar Yilmaz (EUR: Erasmus University Rotterdam)H-Index: 7
Last. Meike W. Vernooij (EUR: Erasmus University Rotterdam)H-Index: 72
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Abstract null null Brain pathology develops at different rates between individuals with similar burden of risk factors, possibly explained by brain resistance. We examined if education contributes to brain resistance by studying its influence on the association between vascular risk factors and brain pathology. null In 4111 stroke-free and dementia-free community-dwelling participants (62.9±10.7 years), we explored the association between vascular risk factors (hypertension and the Framingham St...
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#2Stephanie S. Buss (Harvard University)
Last. Peter J. Fried (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 17
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ABSTRACT null null Prior studies have reported increased cortical excitability in people with Alzheimer's disease (AD), but findings have been inconsistent, and how excitability relates to dementia severity remains incompletely understood. We tested the association between transcranial magnetic stimulation (TMS) measure of motor cortical excitability and cognition in AD. A retrospective cross-sectional analysis investigated the relationship between resting motor threshold (RMT) and the Alzheimer...
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#1Teal S. Eich (SC: University of Southern California)H-Index: 11
#2Patrick J. Lao (Columbia University)H-Index: 12
Last. Michael C. Anderson (Cognition and Brain Sciences Unit)H-Index: 52
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Abstract null null Evidence suggests that older adults have difficulty relative to younger adults in forgetting irrelevant information. Here we sought to understand the physical basis of this deficit by investigating the relationship between cortical thickness and intentional forgetting, using an item-method directed forgetting task. We tested younger (n=44) and older (n=54) adults’ memories for words that they were instructed to either remember or to forget, and then extracted cortical thicknes...
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#1Valentinos Zachariou (UK: University of Kentucky)H-Index: 7
#2Christopher E. Bauer (UK: University of Kentucky)H-Index: 4
Last. Brian T. Gold (UK: University of Kentucky)H-Index: 30
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Abstract null null Age-related brain iron accumulation is linked with oxidative stress, neurodegeneration and cognitive decline. Certain nutrients can reduce brain iron concentration in animal models, however, this association is not well established in humans. Moreover, it remains unknown if nutrition can moderate the effects of age on brain iron concentration and/or cognition. Here, we explored these issues in a sample of seventy-three healthy older adults (61-86 years old), while controlling ...
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#1Julia Pfeil (University of Cologne)
#2Merle C Hoenig (University of Cologne)H-Index: 6
Last. Gérard N. Bischof (University of Cologne)H-Index: 17
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Abstract null null Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia cannot be readily deduced from this binary classification. Here, we assessed if regional patterns of Aβ deposition measured with 18F-florbetapir may serve as biomarker for progression risk in Aβ-positive cognitively normal (CN) and MCI patients, including clini...
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#1Jun-fang Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Hwee Fang Lim (NHS Lothian)
Last. Will Hewins (Edin.: University of Edinburgh)H-Index: 2
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Abstract null null Raised signal in cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) may indicate raised CSF protein or debris and is seen in inferior frontal sulci on routine MRI. To explore its clinical relevance, we assessed the association of inferior frontal sulcal hyperintensities (IFSH) on FLAIR with demographics, risk factors, and small vessel disease markers in three cohorts (healthy volunteers, n=44; mild stroke patients, n=105; older community-dwelling particip...
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