Radiosensitivity, Immune Activation, and Mutational Frequency of Melanoma Metastases Across Tissue Types

Purpose/Objective(s)Melanoma is a more radioresistant and immunogenic histology, associated with a higher mutational burden. However, the influence of metastasis tissue location is unknown. We hypothesize exploiting these differences may allow therapy personalization.Materials/MethodsWe identified metastatic melanoma samples across 6 tissues (brain, liver, lung, lymph node [LN], skin, soft tissue [ST]), which were profiled for gene expression by...