Purpose/Objective(s) null We previously reported the results of a phase II clinical trial evaluating 30-36 Gy of adjuvant radiation therapy (RT) for selected patients with HPV+ OPSCC. Herein we report the two-year results of a phase III trial comparing this 30-36 Gy regimen with standard of care (SOC) adjuvant RT. null null null Materials/Methods null All patients (pts) received transoral robotic surgery (TORS) and neck dissection for a margin negative resection. Pts with pT4 disease or who requ...
#1David A. Palma(LHSU: London Health Sciences Centre)H-Index: 57
#2Eitan Prisman(UBC: University of British Columbia)H-Index: 15
Last. Ian Poon(SHSC : Sunnybrook Health Science Centre)H-Index: 23
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Purpose/Objective(s) null Widespread oral human papillomavirus (HPV) infections have led to a rapid increase in the incidence of oropharyngeal squamous cell carcinoma (OPSCC). HPV-related OPSCCs have a better prognosis than conventional alcohol- and smoking-related OPSCCs, suggesting a role for treatment de-escalation. The goal of this phase II randomized trial was to assess survival, oncologic, and toxicity outcomes with two de-escalation approaches: primary reduced-dose radiotherapy (RT) vs. p...
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