Abstract Purpose The establishment of a preclinical model of the abscopal effect on HCC and evaluation on whether the hypofractionated RT multi-tumor Hepa1-6 mouse HCC model could be used to suppress non-radiated tumor mass would be implemented in this study. Methods and Materials Hepa1-6 mouse liver cancer cell lines were used to form tumors and immunogenicity was analyzed using ELISpot and immune cell labeled antibody. Interferonβ (IFNβ) expression was confirmed through PCR. Results After inve...
PURPOSE Preclinical radiation replicating clinical IMRT techniques can provide data translatable to clinical practice. For this work, treatment plans are created for oxygen-guided dose-painting in small animals utilizing inverse-planned IMRT. Spatially varying beam intensities were achieved using 3D-printed compensators. METHODS AND MATERIALS Optimized beam fluence from arbitrary gantry angles was determined using a verified model of the XRAD225Cx treatment beam. Compensators were 3D-printed wit...
Abstract Purpose Mounting evidence demonstrates that combining radiotherapy (RT) with immunotherapy can reduce tumor burden in a subset of patients. However, conventional systemic delivery of immunotherapeutics is often associated with significant adverse effects, which force treatment cessation. The aim of this study is to investigate a minimally invasive therapeutics delivery approach to improve clinical response while attenuating toxicity. Methods We utilized a nanofluidic drug-eluting seed (...
Abstract Purpose To report trends in the number and types of applicants and matched trainees to radiation oncology in comparison to other specialties participating in the National Resident Matching Program (NRMP) between 2010-2020. Methods Data from the NRMP and Electronic Residency Application System (ERAS) were obtained for 18 medical specialties between 2010-2020. Number and type of applicants and matched trainees relative to available positions in the NRMP and Supplemental Offer and Acceptan...
Last. Vratislav Strnad(FAU: University of Erlangen-Nuremberg)H-Index: 30
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Summary Purpose Second conservative treatment has emerged as an option for patients with second ipsilateral breast tumour event after conserving surgery and breast irradiation. We aimed to address the lack of evidence regarding second breast event treatment by comparing oncological outcomes after conservative treatment or mastectomy. Methods and Materials Oncological outcomes were analysed using a propensity score-matched cohort analysis study on patients diagnosed with a second breast event bet...
Purpose Hypofractionated radiation therapy can be used to treat patients with muscle-invasive bladder cancer unable to have radical therapy. Toxicity is a key concern, but adaptive plan-of the day (POD) image-guided radiation therapy delivery could improve outcomes by minimizing the volume of normal tissue irradiated. The HYBRID trial assessed the multicenter implementation, safety, and efficacy of this strategy. Methods HYBRID is a Phase II randomized trial that was conducted at 14 UK hospitals...