Anticoagulation Agents Inhibit Physiological and Pathological Release of Angiogenic Regulatory Proteins From Platelets Usurping the Innate Angiogenic Potential of Platelets.

2174 While the involvement of platelets in hematogenous tumor metastasis has long been recognized, the cause and effect relationship linking the two remains unclear. Platelets are a reservoir for angiogenic proteins that are both sequestered and secreted in a differentially regulated process (Italiano et al., 2009). We have previously shown that we can manipulate the angiogenic potential of the platelet releasate through physiological (platelet...