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#1Melissa M. Berrien-Elliott (WUSTL: Washington University in St. Louis)H-Index: 16
#2Michelle Becker-Hapak (WUSTL: Washington University in St. Louis)H-Index: 17
Last. Todd A. Fehniger (WUSTL: Washington University in St. Louis)H-Index: 56
view all 23 authors...
NK cells are a promising alternative to T cells for cancer immunotherapy. Adoptive therapies with allogeneic, cytokine-activated NK cells are being investigated in clinical trials. However, the optimal cytokine support after adoptive transfer to promote NK cell expansion, and persistence remains unclear. Correlative studies from two independent clinical trial cohorts treated with MHC-haploidentical NK cell therapy for relapsed/refractory AML revealed that cytokine support by systemic IL-15 (N-80...
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#1Wenbin Zhong (JNU: Jinan University)H-Index: 12
#2Xiuye Cao (JNU: Jinan University)H-Index: 5
Last. Daoguang Yan (JNU: Jinan University)H-Index: 16
view all 10 authors...
Abstract null null Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. Here we report that ORP4L is expressed in ATL cells but not normal T-cells. ORP4L ablation completely blocks T-cell leukemogenesis induced by the HTLV-1 oncoprotein Tax in mice whileengineeringORP4L expression in T-cells results in T-cell leukemia in mice, suggesting the oncogenic properties and prerequisite of ORP4L for the initiation of T-ce...
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#1Joseph E. Italiano (Boston Children's Hospital)H-Index: 60
#2Markus Bender (University of Würzburg)H-Index: 19
Last. Robert Flaumenhaft (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 54
view all 6 authors...
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#1Fengjiao Wang (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 2
#2Jiahuan HeH-Index: 2
Last. Manman HeH-Index: 1
view all 19 authors...
Adenosine-to-inosine (A-to-I) RNA editing and the catalyzing enzyme adenosine deaminase are both essential for hematopoietic development and differentiation. However, the RNA editome during hematopoiesis and the underlying mechanisms are poorly defined. Here, we sorted 12 murine adult hematopoietic cell populations at different stages and identified 30,796 editing sites through RNA sequencing. While the dynamic landscape of the RNA editome comprised of stage/group-specific and stable editing pat...
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#1Seong Lin Khaw (RCH: Royal Children's Hospital)H-Index: 17
#2Paul G Ekert (Peter MacCallum Cancer Centre)H-Index: 50
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#1M. JalinkH-Index: 1
#2Sigbjørn BerentsenH-Index: 21
Last. Masja de Haas (LUMC: Leiden University Medical Center)H-Index: 10
view all 15 authors...
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#1Lucio Luzzatto (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 76
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#1Alessandro Laganà (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 27
#2Samir Parekh (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 28
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#1Abdul Hamid Bazarbachi (Harvard University)H-Index: 3
#2Hervé Avet-LoiseauH-Index: 103
Last. Giovanni Parmigiani (Harvard University)H-Index: 86
view all 14 authors...
Abstract null null IgM multiple myeloma (MM) is a rare disease subgroup. Its differentiation from other IgM-producing gammopathies such as Waldenstrom’s macroglobulinemia (WM) has not been well characterized but is essential for proper risk assessment and treatment. In this study, we investigated genomic and transcriptomic characteristics of IgM-MM samples using whole genome and transcriptome sequencing to identify differentiating characteristics from non-IgM-MM and WM. Our results suggest that ...
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