Elisabeth M. Battinelli
Harvard University
CancerEndothelial stem cellEndocrinologyChemistryImmunologyTumor microenvironmentHemostasisMetastasisMegakaryocyteBone marrowAngiogenesisThrombosisPlatelet activationCancer researchNitric oxideMedicineBiologyPlateletCell biologyPharmacology
Publications 61
#1Harvey G. Roweth (Harvard University)H-Index: 4
#2Elisabeth M. Battinelli (Harvard University)H-Index: 18
Platelets have long been known to play important roles beyond hemostasis and thrombosis. Now recognized as a bonafide mediator of malignant disease, platelets influence various aspects of cancer progression, most notably tumor cell metastasis. Interestingly, platelets isolated from cancer patients often display distinct RNA and protein profiles, with no clear alterations in hemostatic activity. This phenotypically distinct population termed tumor-educated platelets now receive significant attent...
#1Matthew MollH-Index: 7
#2Rebecca L. Zon (Harvard University)H-Index: 2
Last. Jean M. ConnorsH-Index: 36
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#1Olga Pozdnyakova (Brigham and Women's Hospital)H-Index: 19
#2Nathan T. Connell (Harvard University)H-Index: 9
Last. Annette S. Kim (Brigham and Women's Hospital)H-Index: 18
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2 CitationsSource
#1Italo Faria do Valle (NU: Northeastern University)H-Index: 10
#2Harvey G. Roweth (Harvard University)H-Index: 4
Last. Albert-László Barabási (NU: Northeastern University)H-Index: 133
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Polyphenols, natural products present in most plant-based foods, play a protective role against several complex diseases through their antioxidant activity and by diverse molecular mechanisms. Here we developed a network medicine framework to uncover the mechanistic roles of polyphenols on health by considering the molecular interactions between polyphenol protein targets and proteins associated with diseases. We find that the protein targets of polyphenols cluster in specific neighborhoods of t...
1 CitationsSource
#1George A. Alba (Harvard University)H-Index: 7
#2Andriy O. Samokhin (Brigham and Women's Hospital)H-Index: 7
Last. Bradley A. Maron (Brigham and Women's Hospital)H-Index: 29
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Rationale: Data on the molecular mechanisms that regulate platelet-pulmonary endothelial adhesion under conditions of hypoxia are lacking, but may have important therapeutic implications. Objectives: Identify a hypoxia-sensitive, modifiable mediator of platelet-pulmonary artery endothelial cell adhesion and thrombotic remodeling. Methods and Measurements: Network medicine was used to profile protein-protein interactions in hypoxia-treated human pulmonary artery endothelial cells. Data from liqui...
1 CitationsSource
#1Elisabeth M. Battinelli (Brigham and Women's Hospital)H-Index: 18
2 CitationsSource
#1Italo Faria do Valle (NU: Northeastern University)H-Index: 10
#1do Valle (NU: Northeastern University)
Last. Barabasi
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#1Nathan T. Connell (Harvard University)H-Index: 9
#2Elisabeth M. Battinelli (Harvard University)H-Index: 18
Last. Jean M. Connors (Harvard University)H-Index: 36
view all 3 authors...
Abstract Recently in the Journal of Thrombosis and Haemostasis, Harzallah and colleagues report the results of antiphospholipid antibody testing in a series of 56 patients with confirmed or suspected SARS-CoV-2 infection.[1] Twenty-five patients were found to be positive for lupus anticoagulants, while five patients had either anticardiolipin or anti??2-glycoprotein I antibodies. The isotypes for the anticardiolipin and anti??2-glycoprotein I antibodies were reportedly IgG and IgM, although spec...
42 CitationsSource
#1Evan C. Chen (Brigham and Women's Hospital)H-Index: 8
#2Rebecca L. Zon (Brigham and Women's Hospital)H-Index: 4
Last. Jean M. Connors (Brigham and Women's Hospital)H-Index: 36
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Coronavirus disease 2019 (COVID-19) is a current global pandemic caused by the novel coronavirus SARS-CoV-2. Alongside its potential to cause severe respiratory illness, studies have reported a distinct COVID-19-associated coagulopathy that is characterized by elevated D-dimer levels, hyperfibrinogenemia, mild thrombocytopenia, and slight prolongation of the prothrombin time. Studies have also reported increased rates of thromboembolism in patients with COVID-19, but variations in study methodol...
1 CitationsSource
#1Kathryn T. Hall (Brigham and Women's Hospital)H-Index: 15
#2Elisabeth M. Battinelli (Brigham and Women's Hospital)H-Index: 18
Last. Kenneth J. Mukamal (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 67
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Background Genetic variation in catechol‐O‐methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its...
1 CitationsSource