Beth A. Markens
Harvard University
CancerEndothelial stem cellVascular endothelial growth factor AChemistryImmunologyHeparinAspirinAgonistCD24Bone marrowAngiogenesisThromboxane A2Angiogenesis Modulating AgentsPlatelet aggregation inhibitorPlatelet activationCancer researchMedicineEndostatinPlateletPharmacology
8Publications
3H-index
404Citations
Publications 8
Newest
#1Elisabeth M. Battinelli (Harvard University)H-Index: 18
#2Beth A. Markens (Harvard University)H-Index: 3
Last. Joseph E. Italiano (Harvard University)H-Index: 52
view all 6 authors...
Platelets are a reservoir for angiogenic proteins that are secreted in a differentially regulated process. Because of the propensity for clotting, patients with malignancy are often anticoagulated with heparin products, which paradoxically offer a survival benefit by an unknown mechanism. We hypothesized that antithrombotic agents alter the release of angiogenesis regulatory proteins from platelets. Our data revealed that platelets exposed to heparins released significantly decreased vascular en...
73 CitationsSource
#1Elisabeth M. Battinelli (Brigham and Women's Hospital)H-Index: 18
#2Rajesh Kulenthirarajan (Brigham and Women's Hospital)H-Index: 3
Last. Joseph E. Italiano (Brigham and Women's Hospital)H-Index: 52
view all 6 authors...
Platelets are a reservoir for angiogenic proteins that are secreted in a differentially regulated process. While the involvement of platelets in hematogenous tumor metastasis has long been recognized, the cause and effect relationship linking the two remains unclear. Due to the propensity for clotting, patients with malignancy are often anti-coagulated with heparin products, which paradoxically offer a survival benefit by an unknown mechanism. We hypothesized that anti-thrombotic agents alter th...
Source
#1Timothy Marsh (Brigham and Women's Hospital)H-Index: 10
#2Hanna S. Kuznetsov (Brigham and Women's Hospital)H-Index: 2
Last. Sandra S. McAllister (Harvard University)H-Index: 22
view all 11 authors...
Breast cancer recurrence rates vary following treatment, suggesting that tumor cells disseminate early from primary sites but remain indolent indefinitely before progressing to symptomatic disease. The reasons why some indolent disseminated tumors erupt into overt disease are unknown. We discovered a novel process by which certain luminal breast cancer cells and patient tumor specimens (LBC “instigators”) establish a systemic macroenvironment that supports outgrowth of otherwise-indolent dissemi...
Source
#1Hanna S. Kuznetsov (Brigham and Women's Hospital)H-Index: 2
#2Timothy Marsh (Brigham and Women's Hospital)H-Index: 10
Last. Sandra S. McAllister (Harvard University)H-Index: 22
view all 11 authors...
Breast cancer recurrence rates vary following treatment, suggesting that tumor cells disseminate early from primary sites but remain indolent indefinitely before progressing to symptomatic disease. The reasons why some indolent disseminated tumors erupt into overt disease are unknown. We discovered a novel process by which certain luminal breast cancer (LBC) cells and patient tumor specimens (LBC “instigators”) establish a systemic macroenvironment that supports outgrowth of otherwise-indolent d...
91 CitationsSource
#1Elisabeth M. Battinelli (Brigham and Women's Hospital)H-Index: 18
#2Beth A. Markens (Brigham and Women's Hospital)H-Index: 3
Last. Joseph E. Italiano (Brigham and Women's Hospital)H-Index: 52
view all 4 authors...
Abstract 2174 While the involvement of platelets in hematogenous tumor metastasis has long been recognized, the cause and effect relationship linking the two remains unclear. Platelets are a reservoir for angiogenic proteins that are both sequestered and secreted in a differentially regulated process (Italiano et al., 2009). We have previously shown that we can manipulate the angiogenic potential of the platelet releasate through physiological (platelet agonists) and pathological activation (MCF...
Source
#1Elisabeth M. Battinelli (Brigham and Women's Hospital)H-Index: 18
#2Beth A. Markens (Brigham and Women's Hospital)H-Index: 3
Last. Joseph E. Italiano (Brigham and Women's Hospital)H-Index: 52
view all 3 authors...
Abstract 1149 While an association between cancer and platelets has been long recognized, the cause and effect relationship linking the two remains unclear. Provocatively, recent studies suggest that anti-platelet agents can increase overall survival and decrease metastatic disease in cancer patients. Because angiogenesis is crucial for tumor growth beyond 1–2 mm 3 , one view is that platelets may regulate new blood vessel growth through release of the vast array of angiogenesis promoters and st...
3 CitationsSource
#1Elisabeth M. Battinelli (Harvard University)H-Index: 18
#2Beth A. Markens (Harvard University)H-Index: 3
Last. Joseph E. Italiano (Harvard University)H-Index: 52
view all 3 authors...
An association between platelets, angiogenesis, and cancer has long been recognized, but the mechanisms linking them remains unclear. Platelets regulate new blood vessel growth through numerous stimulators and inhibitors of angiogenesis by several pathways, including differential exocytosis of angiogenesis regulators. Herein, we investigated the differential release of angiogenesis stimulators and inhibitors from platelets. Activation of human platelets with adenosine diphosphate (ADP) stimulate...
243 CitationsSource
#1Elisabeth M. Battinelli (Brigham and Women's Hospital)H-Index: 18
#2Joseph E. Italiano (Brigham and Women's Hospital)H-Index: 52
Last. Beth A. Markens (Brigham and Women's Hospital)H-Index: 3
view all 3 authors...
Abstract 649 In addition to their primary roles in hemostasis and thrombosis, platelets participate in other physiological and pathological processes, including inflammation, wound healing, and tumor metastasis. Although platelets are presumed to contribute to angiogenesis by providing numerous pro-and anti-angiogenic factors, the cellular and molecular basis by which platelets regulate angiogenesis is poorly understood. Previously, we have shown that platelets differentially package specific an...
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