P2-140: Convergent Evidence of Pupillary Response as an Early Indicator of Locus Coeruleus Dysfunction and Risk for MCI

There is a great need for early screening tools of Alzheimer’s disease (AD) as pathology may be present decades before symptom onset. Task-evoked pupil dilation (TEPD) is a well-validated measure of mental effort which may detect subtle declines in cognitive efficiency prior to impaired performance. During a digit span task, TEPD increases with cognitive load but decreases after capacity is exceeded. TEPD is also linked to functioning of the...