The possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn’s disease

A link between IgA nephropathy and Crohn’s disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropathy. Intestinal mucosal plasma cells mainly secrete IgA2. Nevertheless, IgA1 deposition is strongly implicated as being the primary cause of IgA nephropathy. A 46-year-old Japanese man developed IgA nephropathy 29 years ago, following...