Haruhito A. Uchida
Okayama University
Internal medicineEndocrinologySurgeryRenal functionCardiologyReceptorChemistryImmunologyInflammationHemodialysisKidney diseaseDiseaseAbdominal aortic aneurysmAngiotensin IIIn patientDiabetes mellitusCalpainApolipoprotein EMedicineBlood pressureGastroenterology
102Publications
15H-index
738Citations
Publications 100
Newest
#2Haruhito A. UchidaH-Index: 15
Last. Ryoko UmebayashiH-Index: 7
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#1Koki MiseH-Index: 15
#2Mariko ImamuraH-Index: 1
Last. Jun WadaH-Index: 63
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#1Yoshiko Hada (Okayama University)H-Index: 2
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 63
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Several studies have reported the efficacy and safety of polyphenols in human health; however, the verification of their efficacy remains insufficient. The aim of this study was to examine whether fisetin, one of flavonoids prevalently present in fruits and vegetables, could suppress lipopolysaccharide- (LPS-) induced inflammatory responses in macrophages. LPS increased proinflammatory mRNA abundance (MCP 1, IL-1β, and iNOS) but were suppressed by fisetin. The increment of nitric oxide by LPS, a...
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#1Mariko NishiwakiH-Index: 1
#2Haruhito A. UchidaH-Index: 15
Last. Jun WadaH-Index: 63
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#1Hannah A. Cooper (TU: Temple University)H-Index: 6
#2Stephanie Cicalese (TU: Temple University)H-Index: 6
Last. Satoru Eguchi (TU: Temple University)H-Index: 37
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AIMS: Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II-associated AAA remains unexplored. Here, we tested the hypothesis that mitochondrial fission is involved in the development of AAA. METHODS AND RESULTS: Immunohistochemistry was ...
11 CitationsSource
#1Nozomu Otaka (Okayama University)H-Index: 4
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 1
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BACKGROUND Vasohibin-2 (VASH2) has been isolated as a homologue of vasohibin-1 (VASH1) that promotes angiogenesis counteracting with VASH1. Chronic angiotensin II (AngII) infusion promotes both ascending and abdominal aortic aneurysms (AAs) in mice. The present study aimed to investigate whether exogenous VASH2 influenced AngII-induced vascular pathology in apolipoprotein E-deficient (ApoE-/-) mice. METHODS Male, ApoE-/- mice (9-14 weeks old) were injected with Ad LacZ or Ad VASH2. After a week,...
1 CitationsSource
#1Yoshiko Hada (Okayama University)H-Index: 2
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 1
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The aim of the present study was to examine whether inhibition of Interleukin (IL)-6 signaling by MR16-1, an IL-6 receptor antibody, attenuates aortitis, cardiac hypertrophy, and arthritis in IL-1 receptor antagonist deficient (IL-1RA KO) mice. Four weeks old mice were intraperitoneally administered with either MR16-1 or non-immune IgG at dosages that were adjusted over time for 5 weeks. These mice were stratified into four groups: MR16-1 treatment groups, KO/MR low group (first 2.0 mg, followin...
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#1Kasumi Yoshinaga (Okayama University)H-Index: 1
#2Motoo Araki (Okayama University)H-Index: 17
Last. Yasutomo Nasu (Okayama University)H-Index: 39
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OBJECTIVES To analyze the effect and impact of low-dose rituximab induction therapy on cytomegalovirus infection in living-donor renal transplantation. METHODS A total of 92 recipients undergoing living-donor renal transplantation at Okayama University Hospital from May 2009 to August 2018 were evaluated retrospectively. Indications for preoperative rituximab (200 mg/body) were the following: (i) ABO major mismatch; (ii) ABO minor mismatch; (iii) donor-specific anti-human leukocyte antigen antib...
1 CitationsSource
#1Ichiro Nojima (Okayama University)H-Index: 1
#2Shingo Eikawa (ISMMS: Icahn School of Medicine at Mount Sinai)
Last. Jun Wada (Okayama University)H-Index: 63
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The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth, which were inhibited by metformin. In CD8 + splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and rev...
1 CitationsSource
#1Yoshiko Hada (Okayama University)H-Index: 2
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun Wada (Okayama University)H-Index: 1
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The world faces the serious problem of aging. In this study, we aimed to investigate the effect of chlorogenic acid (CGA) on vascular senescence. C57/BL6 female mice that were 14 ± 3 months old were infused with either Angiotensin II (AngII) or saline subcutaneously for two weeks. These mice were administered CGA of 20 or 40 mg/kg/day, or saline via oral gavage. AngII infusion developed vascular senescence, which was confirmed by senescence associated-β-galactosidase (SA-β-gal) staining. CGA adm...
2 CitationsSource