Tomohiro Terasaka
University of California, San Diego
Internal medicineEndocrinologySurgeryPathologyReceptorGene knockdownChemistryGonadotropic cellStimulationAndrogenMelatoninLuteinizing hormoneGonadotropinGonadotropin-releasing hormoneAnterior pituitaryBone morphogenetic proteinSecretionMAPK/ERK pathwayHormoneMedicineBiologyGastroenterologyCell biology
37Publications
10H-index
248Citations
Publications 37
Newest
#1Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
#1Lourdes A Esparza (UCSD: University of California, San Diego)H-Index: 3
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 4 authors...
Androgens can affect the reproductive axis of both sexes. In healthy women, as in men, elevated exogenous androgens decrease gonad function and lower gonadotropin levels; such circumstances occur with anabolic steroid abuse or in transgender men (genetic XX individuals) taking androgen supplements. The neuroendocrine mechanisms by which endogenous or exogenous androgens regulate gonadotropin release, including aspects of pulsatile luteinizing hormone (LH) secretion, remain unknown. Because anima...
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#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. Knight (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression in a pituitary gonadotrope cell model and in primary gonadotropes, we show GLUT1-dependent stimulation of glycolysis, but not mitochondrial respiration, by the reproductive neuropeptide GnRH. GnRH stimulation increases gonadotrope GLUT1...
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#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. KnightH-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
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#1Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
#2Danmei Li (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
: A defining characteristic of the hypothalamus-pituitary-gonad reproductive endocrine axis is the episodic secretion of the pituitary gonadotropin hormones LH and FSH by the anterior pituitary gonadotropes. Hormone secretion is dictated by pulsatile stimulation, with GnRH released by hypothalamic neurons that bind and activate the G protein-coupled GnRH receptor expressed by gonadotropes. Hormone secretion and synthesis of gonadotropins are influenced by the amplitude and frequency of GnRH stim...
5 CitationsSource
#1Tomohiro Terasaka (UCSD: University of California, San Diego)H-Index: 10
#2Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 9 authors...
: Gonadotropin secretion, which is elicited by GnRH stimulation of the anterior pituitary gonadotropes, is a critical feature of reproductive control and the maintenance of fertility. In addition, activation of the GnRH receptor (GnRHR) regulates transcription and translation of multiple factors that regulate the signaling response and synthesis of gonadotropins. GnRH stimulation results in a broad redistribution of mRNA between active and inactive polyribosomes within the cell, but the mechanis...
6 CitationsSource
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. Knight (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
Source
#1Song Li (UCSD: University of California, San Diego)H-Index: 2
#2Ekaette F. Mbong (UCSD: University of California, San Diego)H-Index: 4
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 6 authors...
: An emerging body of evidence supports the concept that the pituitary is a site for integration of multiple physiological and metabolic signals that inform and modulate endocrine pathways. Multiple endocrine mediators of energy balance and adiposity are known to impinge on the neuroendocrine axis regulating reproduction. Observations in humans show that obesity is correlated with decreased gonadotropin secretion, and studies have also suggested that pituitary sensitivity to stimulation by gonad...
7 CitationsSource
#1Tomohiro Terasaka (UCSD: University of California, San Diego)H-Index: 10
#2Mary E. Adakama (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
Biological rhythms lie at the center of regulatory schemes that control many aspects of living systems. At the cellular level, meaningful responses to external stimuli depend on propagation and quenching of a signal to maintain vigilance for subsequent stimulation or changes that serve to shape and modulate the response. The hypothalamus-pituitary-gonad endocrine axis that controls reproductive development and function relies on control through rhythmic stimulation. Central to this axis is the p...
8 CitationsSource
#1Ko Harada (Okayama University)H-Index: 3
#2Kosuke Kimura (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 9 authors...
: Objective To analyze the clinical and endocrine characteristics of patients with primary adrenal lymphoma. Patients We retrospectively reviewed the cases of five patients with primary adrenal lymphoma who were treated in our hospital between April 2004 and March 2015. We investigated the characteristics of the clinical and pathological findings, treatment, prognosis and complications of adrenal insufficiency. Results Adrenal insufficiency, which was confirmed by the laboratory data at the init...
4 CitationsSource
#1Kosuke Kimura (Okayama University)H-Index: 5
#2Tomohiro Terasaka (Okayama University)H-Index: 10
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 8 authors...
Osteoblasts undergo differentiation in response to various factors, including growth factors and steroids. Bone mass is diminished in androgen- and/or growth hormone (GH)-deficient patients. However the functional relationship between androgen and GH, and their combined effects on bone metabolism, remains unclear. Here we investigated the mutual effects of androgen and GH on osteoblastic marker expression using mouse myoblastic C2C12 and osteoblast-like MC3T3-E1 cells. Combined treatment with di...
10 CitationsSource