Jun Wada
Okayama University
Internal medicineEndocrinologySurgeryPathologyMolecular biologyRenal functionChemistryImmunologyType 2 diabetesKidney diseaseProteinuriaDiabetic nephropathyKidneyMetabolic syndromeNephropathyDiabetes mellitusMedicineBiologyGastroenterologyCell biology
447Publications
63H-index
10.2kCitations
Publications 445
Newest
#2Haruhito A. UchidaH-Index: 15
Last. Ryoko UmebayashiH-Index: 7
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#1Kasumi Yoshinaga (Okayama University)H-Index: 1
#2Motoo Araki (Okayama University)H-Index: 17
Last. Shingo Nishimura (Okayama University)H-Index: 2
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OBJECTIVES To compare the donor outcomes of living donor kidney transplantation between standard donors (SDs) and marginal donors (MDs) including diabetic patients (MD + DM). METHODS MDs were defined according to Japanese guideline criteria: (a) age >70-years, (b) blood pressure ≤130/80 mmHg on hypertension medicine, (c) body mass index >25 to ≤32 kg/m2 , (d) 24-h creatinine clearance ≥70 to null 6.2 or ≤6.5 with oral diabetic medicine. Fifty-three of 114 donors were MDs. We compared donor kidne...
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#1Yusuke Fukuyasu (Okayama University)H-Index: 1
#2Hitomi Kataoka (Okayama University)H-Index: 9
Last. Joseph S. Gonnella (Thomas Jefferson University)H-Index: 54
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BACKGROUND Empathy, which involves understanding another person's experiences and concerns, is an important component for developing physicians' overall competence. This longitudinal study was designed to test the hypothesis that medical students' empathy can be enhanced and sustained by Humanitude Care Methodology, which focuses on perception, emotion and speech. METHODS This six-year longitudinal observational study examined 115 students who entered Okayama University Medical School in 2013. T...
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Activity of transcription factors is normally regulated through interaction with other transcription factors, chromatin remodeling proteins and transcriptional co-activators. In distinction to these well-established transcriptional controls of gene expression, we have uncovered a unique activation model of transcription factors between tyrosine kinase ABL and RUNX2, an osteoblastic master transcription factor, for cancer invasion. We show that ABL directly binds to, phosphorylates, and activates...
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#1Shogo Watari (Okayama University)H-Index: 1
#2Motoo Araki (Okayama University)H-Index: 17
Last. Shingo Nishimura (Okayama University)H-Index: 2
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Abstract null null We evaluated the impact of vonoprazan on blood concentrations of tacrolimus via a retrospective analysis of 52 renal transplant recipients who took tacrolimus and converted from rabeprazole to vonoprazan between August 2018 and September 2019. We compared tacrolimus trough levels upon conversion among groups that were classified based on cytochrome P450 (CYP) gene polymorphisms. CYP3A5 groups were heterozygous or homozygous for CYP3A5*1 and CYP3A5*3 alleles. CYP2C19 genotypes ...
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#1Koki MiseH-Index: 15
#2Mariko ImamuraH-Index: 1
Last. Jun WadaH-Index: 63
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#1Shogo Watari (Okayama University)H-Index: 1
#2Motoo Araki (Okayama University)H-Index: 17
Last. Yasutomo Nasu (Okayama University)H-Index: 39
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ABSTRACT Background We investigated the association between ABO-incompatible (ABO-I) kidney transplantation and early graft function. Methods We retrospectively analyzed 95 patients who underwent living donor kidney transplantation between May 2009 and July 2019. It included 61 ABO-compatible (ABO-C) and 34 ABO-I transplantations. We extracted data on immunologic profile, sex, age, cold ischemic time, type of immunosuppression, and graft function. Two definitions were used for slow graft functio...
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#1Satoshi Fujisawa (Okayama University)H-Index: 3
#2Motoshi Komatsubara (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
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Orexin is expressed mainly in the hypothalamus and is known to activate the hypothalamic-pituitary-adrenal (HPA) axis that is involved in various stress responses and its resilience. However, the effects of orexin on the endocrine function of pituitary corticotrope cells remain unclear. In this study, we investigated the roles of orexin A in pro-opiomelanocortin (POMC) transcription using mouse corticotrope AtT20 cells, focusing on the bone morphogenetic protein (BMP) system expressed in the pit...
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#1Yosuke Asano (Okayama University)H-Index: 4
#2Yoshinori Matsumoto (Okayama University)H-Index: 12
Last. Jun Wada (Okayama University)H-Index: 63
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Bone is a highly dynamic organ that undergoes remodeling equally regulated by osteoblast-mediated bone formation and osteoclast-mediated bone resorption. To clarify the regulation of osteoblastogenesis, primary murine osteoblasts are required for an in vitro study. Primary osteoblasts are isolated from neonatal calvariae through digestion with collagenase. However, the number of cells collected from one pup is not sufficient for further in vitro experiments, leading to an increase in the use of ...
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#1Masayuki Kuroda (Chiba University)H-Index: 9
#2Hideaki Bujo (Toho University)H-Index: 37
Last. Mariko Harada-ShibaH-Index: 39
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Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial ...
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