Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients
Abstract
Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortisol on brain volume, memory, and cell metabolism. However, the cellular and transcriptomic changes that occur in the brain after prolonged exposure to cortisol are less understood. Furthermore, the...
Paper Details
Title
Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients
Published Date
Nov 30, 2021
Journal
Volume
11
Issue
1
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