Translational Psychiatry
Papers 2,901
1 page of 291 pages (2,901 results)
#1Louise Carton (UDL: University of Lille)H-Index: 4
Last. Julie Deguil (UDL: University of Lille)H-Index: 2
view all 9 authors...
Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and whether there is an age-dependent effect. One hundred and five C57Bl/6 male mice were randomly assigned to the 15 mg/kg/day, the 30 mg/kg/day diazepam-supplemented pellets, or the control group. Each group c...
#1Daria Piacentino (NIH: National Institutes of Health)H-Index: 15
#2Silvia Grant-Beurmann (UMAB: University of Maryland, Baltimore)H-Index: 1
Last. Lorenzo LeggioH-Index: 42
view all 11 authors...
A relationship between the gut microbiome and alcohol use disorder has been suggested. Excessive alcohol use produces changes in the fecal microbiome and metabolome in both rodents and humans. Yet, these changes can be observed only in a subgroup of the studied populations, and reversal does not always occur after abstinence. We aimed to analyze fecal microbial composition and function in a translationally relevant baboon model of chronic heavy drinking that also meets binge criteria (drinking t...
#1Kelly J. Heard (Salk Institute for Biological Studies)H-Index: 5
#2Maxim N. Shokhirev (Salk Institute for Biological Studies)H-Index: 27
Last. Krishna C. Vadodaria (Salk Institute for Biological Studies)H-Index: 17
view all 13 authors...
Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortisol on brain volume, memory, and cell metabolism. However, the cellular and transcriptomic changes that occur in the brain after prolonged exposure to cortisol are less understood. Furthermore, the astrocyte-specific contribution to cortisol-induced n...
#1Klaus Oliver Schubert (University of Adelaide)H-Index: 13
#2Anbupalam Thalamuthu (UNSW: UNSW Sydney)H-Index: 34
Last. Bernhard T. Baune (WWU: University of Münster)H-Index: 74
view all 116 authors...
Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well understood, and personalized treatment in BD remains elusive. Genetic analyses of the lithium treatment response phenotype may generate novel molecular insights into lithium's therapeutic mechanisms and lead to testable hypotheses to improve BD management and outcomes. We used fixed effect meta-a...
#1Wenting Fang (FJMU: Fujian Medical University)H-Index: 4
#2Naian Xiao (XMU: Xiamen University)H-Index: 1
Last. Jing Zhang (FJMU: Fujian Medical University)H-Index: 18
view all 9 authors...
#1Rong Ren (SCU: Sichuan University)H-Index: 11
#2Ye Zhang (SCU: Sichuan University)H-Index: 9
Last. Xiangdong Tang (SCU: Sichuan University)H-Index: 30
view all 5 authors...
Previous studies on the association of insomnia with body mass index (BMI) have been controversial. Physiological hyperarousal, the key pathological mechanism of insomnia, may be an important reason for different findings. We explored whether insomnia with physiological hyperarousal measured by the multiple sleep latency test (MSLT) is associated with body-weight differences. A total of 185 normal sleepers and 440 insomniacs were included in this study. Insomnia was defined by standard diagnosti...
#1Kelly Smart (Yale University)H-Index: 8
#2Ashley YttredahlH-Index: 3
Last. Jeffrey M. MillerH-Index: 18
view all 7 authors...
Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component ...
#1Zachary M. Harvanek (Yale University)H-Index: 6
#2Nia Fogelman (Yale University)H-Index: 6
Last. Rajita SinhaH-Index: 78
view all 4 authors...
Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether resilience factors affect stress-associated biological age acceleration. Recently developed null clocks such as GrimAge have shown utility in predicting biological age and mortality. Here, we assessed the impact...
#1Lukasz Smigielski (UZH: University of Zurich)H-Index: 6
#2Sergi Papiol (LMU: Ludwig-Maximilians-Universität München)H-Index: 20
Last. Edna Grünblatt (UZH: University of Zurich)H-Index: 42
view all 60 authors...
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity gradients. PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using...
#1J. Blair Price (Deakin University)H-Index: 3
#2Clarissa Yates (UQ: University of Queensland)
Last. Susannah J. TyeH-Index: 22
view all 9 authors...
Lithium, a mood stabilizer and common adjunctive treatment for refractory depression, shares overlapping mechanisms of action with ketamine and enhances the duration of ketamine’s antidepressant actions in rodent models at sub-therapeutic doses. Yet, in a recent clinical trial, lithium co-treatment with ketamine failed to improve antidepressant outcomes in subjects previously shown to respond to ketamine alone. The potential for lithium augmentation to improve antidepressant outcomes in ketamine...
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