Higher Radiation Doses to Motor Regions Predict Decline in Fine Motor Skills After Brain RT: NTCP Analysis of a Prospective Trial

Impairment in fine motor skills (FMS), including motor speed and coordination, can occur after brain radiotherapy. FMS are essential for activities of daily living including writing, typing, and eating. Using a normal tissue complication probability (NTCP) framework, we sought to determine dosimetric predictors of FMS decline in a prospective cohort of brain tumor patients treated with RT.On a prospective clinical trial, 52 primary brain tumor...