Mia A Salans
University of California, San Diego
CancerInternal medicineOncologyLogistic regressionNeurocognitiveEsophagusBrain tumorDiseaseEsophageal cancerNivolumabProstate cancerAtrophyWhite matterIpilimumabNuclear medicineIn patientCost effectivenessOverall survivalPerioperativeRadiation therapyMedicineFractional anisotropy
18Publications
3H-index
13Citations
Publications 24
Newest
Purpose/Objective(s) null SRS for brain metastases is associated with a high rate (52%-64%) of cognitive deterioration. We performed a phase II clinical trial of critical white matter and hippocampal sparing brain SRS in patients with limited brain metastases, to improve cognitive preservation. We present feasibility of this approach and interim results. null null null Materials/Methods null Adult patients with limited volume ( null 6 months, pathologic confirmation of malignancy. Prior WBRT was...
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#6J. Yu (UCSD: University of California, San Diego)
#7A.S. Qian (UCSD: University of California, San Diego)
PURPOSE/OBJECTIVE(S) Impairment in fine motor skills (FMS), including motor speed and coordination, can occur after brain radiotherapy. FMS are essential for activities of daily living including writing, typing, and eating. Using a normal tissue complication probability (NTCP) framework, we sought to determine dosimetric predictors of FMS decline in a prospective cohort of brain tumor patients treated with RT. MATERIALS/METHODS On a prospective clinical trial, 52 primary brain tumor patients rec...
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#1J. Yu (UCSD: University of California, San Diego)
#8A.S. Qian (UCSD: University of California, San Diego)
PURPOSE/OBJECTIVE(S) The entorhinal cortex in the medial temporal lobe is a critical part of the hippocampal memory system, crucial for memory formation and consolidation. Studies show the entorhinal cortex is particularly vulnerable to dose-dependent atrophy. We examined the association between entorhinal cortical volume and longitudinal verbal and visuospatial memory function in a prospective cohort of primary brain tumor patients. MATERIALS/METHODS Primary brain tumor patients (n = 50) underg...
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Purpose/Objective(s) null Attention and processing speed, an important neurocognitive function, is subserved in the brain by critical white matter (WM): the corpus callosum (CC) and intra-hemispheric white matter tracts (IHWM). We sought to characterize the dose-response relationship of these structures with decline in attention/processing speed at 6 months post-RT in patients with primary brain tumors, with particular attention to low doses. null null null Materials/Methods null On a prospectiv...
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#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Patrick T Courtney (UCSD: University of California, San Diego)H-Index: 2
Last. James D. Murphy (UCSD: University of California, San Diego)H-Index: 39
view all 4 authors...
BACKGROUND Adjuvant ipilimumab was found to improve the overall survival and reduce toxicity compared to high-dose interferon (HDI) in patients with resected, high-risk melanoma. However, the cost of ipilimumab is substantially higher than HDI. This study evaluates the cost-effectiveness of ipilimumab as an adjuvant treatment in melanoma from a healthcare perspective. METHODS We designed a Markov model simulating resected, high-risk melanoma patients receiving either ipilimumab or HDI. Transitio...
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#1Mia A Salans (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#7Deborah C. Marshall (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
Last. Yoseph Dalia (UT: University of Tennessee)H-Index: 2
view all 15 authors...
Objective null We conducted a prospective clinical trial of patients receiving radiation (RT) for brain metastases to identify clinical predictors of pre-RT and post-RT health-related quality of life (hrQoL). null Materials and methods null Patients with brain metastases completed overall (European Organisation for Research and Treatment of Cancer QLQ C15-PAL) and brain tumor-specific (QLQ-BN20) hrQoL assessments pre-RT (n=127) and 1 (n=56) and 3 (n=45) months post-RT. Linear and proportional-od...
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#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 10 authors...
BACKGROUND We explored fine motor skills (FMS) before and after brain radiotherapy (RT), analyzing associations between longitudinal FMS and imaging biomarkers of cortical and white matter (WM) integrity in motor regions of interest (ROIs). METHODS On a prospective trial, 52 primary brain tumor patients receiving fractionated brain RT underwent volumetric brain MRI, diffusion tensor imaging, and FMS assessments (Delis-Kaplan Executive Function System Trail Making Test Motor Speed [DKEFS-MS], Gro...
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#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
Last. Tonya M. Pan-Weisz (UCSD: University of California, San Diego)H-Index: 3
view all 12 authors...
ABSTRACT null null Background null We conducted the first prospective longitudinal study examining the independent association between patient-reported hrQoL (physical, social/family, emotional, functional, and brain cancer-specific) and neurocognitive function (NCF), while controlling for mood symptoms in primary brain tumor patients. null null null Methods null Primary brain tumor patients (n=59) receiving brain radiotherapy (RT) underwent hrQOL (Functional Assessment of Cancer Therapy-Brain),...
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#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 4 authors...
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#1P Travis Courtney (UCSD: University of California, San Diego)H-Index: 2
#2Anthony Yip (UCSD: University of California, San Diego)H-Index: 2
Last. James D. Murphy (UCSD: University of California, San Diego)H-Index: 39
view all 6 authors...
Importance Treatment with nivolumab-ipilimumab combination therapy was found to improve overall survival compared with chemotherapy among patients with advanced non–small cell lung cancer (NSCLC) in the CheckMate 227 clinical trial. However, these drugs are substantially more expensive than chemotherapy and, given the high incidence of advanced NSCLC, the incorporation of dual immune checkpoint inhibitors into the standard of care could have substantial economic consequences. Objective To assess...
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