Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort

To compare the effectiveness of initial treatment for infantile spasms.The National Infantile Spasms Consortium prospectively followed up children with new-onset infantile spasms that began at age 2 to 24 months at 23 US centers (2012-2018). Freedom from treatment failure at 60 days required no second treatment for infantile spasms and no clinical spasms after 30 days of treatment initiation. We managed treatment selection bias with propensity...