Renée A. Shellhaas
University of Michigan
Internal medicineEtiologyNeurointensive careIntensive care medicinePediatricsProspective cohort studyCohort studyStatus epilepticusEpilepsyPolysomnographyGestational agePhenobarbitalNeonatal seizurePopulationSymptomatic seizuresIntensive careAnesthesiaElectroencephalographyMedicineCohort
Publications 133
#1Emily M. Herzberg (Harvard University)H-Index: 2
#2Michelle Machie (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
Last. Dennis J. Dlugos (UPenn: University of Pennsylvania)H-Index: 57
view all 17 authors...
OBJECTIVE To characterize intracranial hemorrhage (ICH) as a seizure etiology in infants born at term and preterm. For term infants, to compare seizure severity and treatment response for multi-site vs single-site ICH and hypoxic-ischemic encephalopathy (HIE) with vs. without ICH. STUDY DESIGN We studied 112 newborn infants with seizures attributed to ICH, and 201 infants born at term with seizures attributed to HIE, using a cohort of consecutive infants with clinically diagnosed and/or electrog...
#1Monica E. Lemmon (Duke University)H-Index: 15
#2Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 39
Last. Taeun Chang (GW: George Washington University)H-Index: 31
view all 19 authors...
Abstract null null Purpose null Parents of neonates with seizures are at risk of mental health symptoms due to the impact of illness on family life, prognostic uncertainty, and the emotional toll of hospitalization. A family-centered approach is the preferred model to mitigate these challenges. We aimed to identify strategies to promote family-centered care through an analysis of parent-offered advice to clinicians caring for neonates with seizures. null null null Basic procedures null This pros...
#1Shavonne L Massey (UPenn: University of Pennsylvania)H-Index: 6
#2Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 39
Last. Nicholas S. Abend (UPenn: University of Pennsylvania)H-Index: 48
view all 14 authors...
Objective null To compare key seizure and outcome characteristics between neonates with and without cardiopulmonary disease (CPD). null null null Study design null The Neonatal Seizure Registry (NSR-1) is a multicenter, prospectively acquired cohort of neonates with clinical or EEG-confirmed seizures. CPD was defined as congenital heart disease, congenital diaphragmatic hernia, and exposure to extracorporeal membrane oxygenation. We assessed continuous electroencephalographic monitoring (cEEG) s...
#1Taryn-Leigh Surtees (WashU: Washington University in St. Louis)
#2Ishani Kumar (UM: University of Michigan)
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 31
view all 8 authors...
Abstract null null Background null Prophylactic antiseizure medications (ASMs) for pediatric traumatic brain injury (TBI) are understudied. We evaluated clinical and radiographic features that inform prescription of ASMs for pediatric TBI. We hypothesized that despite a lack of evidence, levetiracetam is the preferred prophylactic ASM but that prophylaxis is inconsistently prescribed. null null null Methods null This retrospective study assessed children admitted with TBI from January 1, 2017, t...
#1Jennifer Keene (UW: University of Washington)
#2Lindsey A. Morgan (UW: University of Washington)H-Index: 6
Last. Niranjana Natarajan (UW: University of Washington)H-Index: 5
view all 16 authors...
Abstract null null Objective null Seizures are a common neonatal neurologic emergency. Many centers have developed pathways to optimize management. We evaluated neonatal seizure management pathways at level IV neonatal intensive care units (NICUs) in the United States to highlight areas of consensus and describe aspects of variability. null null null Methods null We conducted a descriptive analysis of 11 neonatal seizure management pathways from level IV NICUs that specialize in neonatal neurocr...
#1Renée A. Shellhaas (UM: University of Michigan)H-Index: 31
#2Gabrielle deVeberH-Index: 88
Last. Hannah C. Glass (UCSF: University of California, San Francisco)H-Index: 39
view all 24 authors...
Background null Gene-targeted therapies are becoming a reality for infants and children with diseases of the nervous system. Rapid scientific advances have led to disease-modifying or even curative treatments. However, delays and gaps in diagnosis, inequitable delivery, and the need for long-term surveillance pose unresolved challenges. null Objective and methods null The goal of the Child Neurology Society Research Committee was to evaluate and provide guidance on the obstacles, opportunities, ...
#1Theodore Sheehan (Boston Children's Hospital)H-Index: 1
#2Marta Amengual-Gual (UIB: University of the Balearic Islands)H-Index: 8
Last. Jessica L. Carpenter (GW: George Washington University)H-Index: 21
view all 46 authors...
OBJECTIVE This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non-BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). METHODS This retrospective multicenter study in the United States and Canada used prospectively collected observational data from children admitted with rSE between 2011 and 2020. Outcome variables were the number of BZDs given before the first non-BZD ASM, and the numbe...
#1Julie Ziobro (UM: University of Michigan)H-Index: 8
#2Krista Eschbach (CU: University of Colorado Boulder)H-Index: 6
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 31
view all 3 authors...
Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and pathophysiologic understanding of the distinct features of acute symptomatic seizures and neonatal-onset epilepsies present exceptional opportunities for development of precision therapies with potential to improve outcomes. Herein, we discuss the pathophysiology of neonatal seizures and review the evidence for currently available treatment. We present ...
#2Janette Mailo (Glenrose Rehabilitation Hospital)H-Index: 1
Last. Taeun Chang (GW: George Washington University)H-Index: 31
view all 10 authors...
Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures - about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed seizures. These seizures are best identified with continuous EEG monitoring, as clinical diagnosis leads to under-diagnosis of subclinical seizures and over-treatment of events that are not seizures. High seizure burden, especially status epilepticus, is thought to augment brain injury. Treatment, therefore, is aimed at minimi...
#1Jea Young Min (Cornell University)H-Index: 8
#2Kelly G. Knupp (Anschutz Medical Campus)H-Index: 20
Last. Zachary M. Grinspan (Cornell University)H-Index: 18
view all 6 authors...
OBJECTIVE There are three recommended first-line treatments for infantile spasms, adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin, though non-standard treatments such as topiramate are sometimes selected. Is it uncertain how treatment selection influences health services outcomes. METHODS We conducted a retrospective cohort study of Medicaid beneficiaries newly diagnosed with infantile spasms from 2009-2010. We included infants with a new diagnosis of infantile spasms be...
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