Last. Gary Cutter(UAB: University of Alabama at Birmingham)H-Index: 113
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Background: null Clinical trials in relapsing-remitting multiple sclerosis (RRMS) usually use the Expanded Disability Status Scale (EDSS) as their primary disability outcome measure, while the more recently developed outcomes timed 25 foot walk (T25FW) and nine hole peg test (NHPT) may be more useful and patient-relevant. null Objective: null To compare the EDSS to the T25FW and NHPT in a large RRMS randomized controlled trial (RCT) dataset. null Methods: null We used the dataset from CombiRx (c...
Objective: null To test the hypothesis that a history of concussion (HOC) causes greater disturbances in cerebral blood flow (CBF) and white matter microstructure of midline brain structures after subsequent concussions, during the acute and chronic phases of recovery. null Methods: null In this longitudinal magnetic resonance imaging (MRI) study, 61 athletes with uncomplicated concussion (36 with HOC) were imaged at the acute phase of injury (1 to 7 days post-injury), the subacute phase (8 to 1...
BACKGROUND AND OBJECTIVES Observational research has shown that a substantial proportion of all dementia cases worldwide is attributable to modifiable risk factors. Dementia risk scores might be useful to identify high-risk individuals and monitor treatment adherence. The objective of this study was to investigate whether a dementia risk score, the LIfestyle for BRAin health (LIBRA) index, is associated with MRI markers and cognitive functioning/impairment in the general population. METHODS Cros...
#### Notable in Neurology This Week This issue features an article that investigates whether IV thrombolysis treatment before endovascular thrombectomy (ET) results in better outcomes than ET alone in patients with large artery occlusion stroke; another examines the association of Lewy bodies with olfactory disfunction, parkinsonism, and dementia among Black and White elderly adults. A featured Research Methods in Neurology article evaluates the shortcomings of the modified Rankin …
Objective: null To explore the spectrum of skeletal muscle and nerve pathology of patients who died following SARS-CoV-2 infection and assess for direct viral invasion of these tissues. null Methods: null Psoas muscle and femoral nerve sampled from 35 consecutive autopsies of patients who died following SARS-CoV-2 infection and 10 SARS-CoV-2-negative controls were examined under light microscopy. Clinical and laboratory data were obtained by chart review. null Results: null In SARS-CoV-2-positiv...
Dr. Guterman et al. reported a cross-sectional analysis of 2,494 adult patients with status epilepticus treated by an emergency medical services agency from 2013 to 2018, of whom 1,537 patients received midazolam. They found that higher midazolam doses were associated with reduced use of rescue therapy without an increased need for ventilator support. In response, Dr. Kellinghaus et al. note that the findings are in keeping with their data from a large European prospective registry, which showed...