#2Carmen Tur(UCL Institute of Neurology)H-Index: 27
Last. Frederik Barkhof(UCL: University College London)H-Index: 134
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While the armamentarium to treat relapsing-remitting multiple sclerosis MS is ever-expanding, the choice of drugs to treat progressive forms of the disease remains limited. Although (ongoing) inflammation may play a role in neurodegeneration, other mechanisms are likely to contribute to it, and there is a need to identify drugs with a neuroprotective mode of action. Ibudilast is a drug that has previously been suggested to have a neuroprotective effect in relapsing-remitting MS1: ibudilast (60 m...
A 29-year-old woman with relapsed T-cell acute lymphoblastic leukemia presented with 4 months of progressive ataxia, weakness, and bowel/bladder incontinence. Symptoms started after completing 2 cycles of nelarabine. Examination revealed paraplegia and complete sensory loss from mid-chest down, loss of vibration and joint position in upper limbs, areflexia, and bilateral Babinski signs. EMG showed fibrillation potentials with no activated motor units in lower limbs. Laboratory workup, including ...
#2Alex Rovira(Autonomous University of Barcelona)H-Index: 59
Last. Mar Tintoré(Autonomous University of Barcelona)H-Index: 50
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Objective: To assess the added value of the optic nerve region (by using visual evoked potentials-VEPs-) to the current diagnostic criteria. Methods: From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time (DIT) at baseline (n=388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS c...
OBJECTIVE To test the hypothesis that myeloneuropathy is a presenting phenotype of paraneoplastic neurologic syndromes we retrospectively reviewed clinical, radiologic, and serologic features of 32 patients with concomitant paraneoplastic spinal cord and peripheral nervous system involvement. METHODS Observational study investigating patients with myeloneuropathy and underlying cancer or onconeural antibody seropositivity. RESULTS Among 32 patients with paraneoplastic myeloneuropathy, 20 (63%) w...
OBJECTIVE To determine whether ibudilast has an effect on brain volume and new lesions in progressive forms of multiple sclerosis (MS). METHODS A randomized, placebo-controlled, blinded study evaluated ibudilast at a dose of up to 100 mg over 96 weeks in primary and secondary progressive MS. In this secondary analysis of a previously reported trial, secondary and tertiary endpoints included gray matter atrophy, new or enlarging T2 lesions as measured every 24 weeks, and new T1 hypointensities at...
A 96-year-old woman was admitted to the emergency department with generalized epileptic seizures and fever followed by left hemiparesis. Two days before admission, she had developed anosmia, dysgeusia,1 and behavioral dysexecutive syndrome. No respiratory symptoms were present or reported. Whereas nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription PCR was negative, chest CT scan showed several lung areas of ground-glass opacity and intralobular cros...
Objective To examine the effect of sex on clinical response to triptans and to determine whether these differences are related to pharmacokinetics of triptans in men and women, we performed a systematic review and meta-analysis. Methods We searched clinical trials distinguishing clinical response to or pharmacokinetic parameters of triptans between sexes in PubMed, MEDLINE, Cochrane Library, Embase and Web of Science up to Dec 12, 2019. Analysis was based on data extracted from published reports...
Objective: To establish progression of imaging biomarkers of stroke, arterial steno-occlusive disease and white matter injury in patients with smooth muscle dysfunction syndrome caused by mutations in the ACTA2 gene, we analyzed 113 cerebral MRI scans from a retrospective cohort of 27 patients with ACTA2 Arg179 pathogenic variants. Methods: Systematic quantifications of arterial ischemic strokes and white matter lesions were performed on baseline and follow-up scans using planimetric methods. Cr...