Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
Abstract
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor outcomes, and is associated with a greater degree of cognitive impairment and depressive symptoms, compared to subjects without psychosis (AD - P). Although the estimated heritability of AD + P is 61%, genetic sources of risk are...
Paper Details
Title
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
Published Date
Jun 10, 2021
Journal
Volume
26
Issue
10
Pages
5797 - 5811
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