Molecular Psychiatry
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12.38
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4379
Papers 4823
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#1Johannes Kornhuber (FAU: University of Erlangen-Nuremberg)H-Index: 103
#2Nicolas Hoertel (French Institute of Health and Medical Research)H-Index: 23
Last. Erich Gulbins (UC: University of Cincinnati)H-Index: 100
view all 3 authors...
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry. Lowering the amount of ceramide or ceramide blockade due to inhibitors of ASM, genetic downregulation of ASM, anti-ceramide antibodies or degradation by neutral ceramidase protected against infection with SARS-CoV-2. The addition of ceramide restored infection with SARS-CoV-2. Many ...
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#1Marco Bucci (KI: Karolinska Institutet)
#2Konstantinos Chiotis (KI: Karolinska Institutet)H-Index: 19
view all 4 authors...
For early detection of Alzheimer’s disease, it is important to find biomarkers with predictive value for disease progression and clinical manifestations, such as cognitive decline. Individuals can now be profiled based on their biomarker status for Aβ42 (A) or tau (T) deposition and neurodegeneration (N). The aim of this study was to compare the cerebrospinal fluid (CSF) and imaging (PET/MR) biomarkers in each ATN category and to assess their ability to predict longitudinal cognitive decline. A ...
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#1Elena Rodriguez-Vieitez (Harvard University)H-Index: 1
#2Victor Montal (Autonomous University of Barcelona)H-Index: 13
Last. Rebecca Amariglio (Harvard University)H-Index: 37
view all 16 authors...
Noninvasive biomarkers of early neuronal injury may help identify cognitively normal individuals at risk of developing Alzheimer’s disease (AD). A recent diffusion-weighted imaging (DWI) method allows assessing cortical microstructure via cortical mean diffusivity (cMD), suggested to be more sensitive than macrostructural neurodegeneration. Here, we aimed to investigate the association of cMD with amyloid-β and tau pathology in older adults, and whether cMD predicts longitudinal cognitive declin...
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#1Chunyan Luo (Sichuan University)H-Index: 15
#2XueNan Pi (Sichuan University)
Last. Dan Xie (Sichuan University)
view all 11 authors...
Epigenetic modifications are plausible molecular sources of phenotypic heterogeneity across schizophrenia patients. The current study investigated biological heterogeneity in schizophrenia using peripheral epigenetic profiles to delineate illness subtypes independent of their phenomenological manifestations. We applied epigenome-wide profiling with a DNA methylation array from blood samples of 63 schizophrenia patients and 59 healthy controls. Non-negative matrix factorization (NMF) and k-means ...
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#1Tomomi Nakahara (Keio: Keio University)H-Index: 1
#2Sakiko Tsugawa (Keio: Keio University)H-Index: 8
Last. Honoka Watanabe (Keio: Keio University)
view all 22 authors...
Background null The glutamate (Glu) and gamma aminobutyric acid (GABA) hypotheses of schizophrenia were proposed in the 1980s. However, current findings on those metabolite levels in schizophrenia have been inconsistent, and the relationship between their abnormalities and the pathophysiology of schizophrenia remains unclear. To summarize the nature of the alterations of glutamatergic and GABAergic systems in schizophrenia, we conducted meta-analyses of proton magnetic resonance spectroscopy (1H...
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#1Liubov S. Kalinichenko (FAU: University of Erlangen-Nuremberg)H-Index: 6
#2Christiane Mühle (FAU: University of Erlangen-Nuremberg)H-Index: 24
Last. Julia Hohenschild (FAU: University of Erlangen-Nuremberg)
view all 58 authors...
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation. Functional analysis in mice showed that NSM controls ...
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#1Kai Yuan (PKU: Peking University)H-Index: 8
#2Xiao-Lin Huang (CAS: Chinese Academy of Sciences)
Last. Ze Yuan (CAS: Chinese Academy of Sciences)
view all 24 authors...
Infectious diseases, including COVID-19, are crucial public health issues and may lead to considerable fear among the general public and stigmatization of, and discrimination against, specific populations. This meta-analysis aimed to estimate the pooled prevalence of stigma in infectious disease epidemics. We systematically searched PubMed, PsycINFO, Embase, MEDLINE, Web of Science, and Cochrane databases since inception to June 08, 2021, and reported the prevalence of stigma towards people with...
1 CitationsSource
#1Ling Gong (Fudan University)H-Index: 3
#2Xue Liu (Fudan University)
Last. Miao He (Fudan University)H-Index: 17
view all 4 authors...
The mammalian brain is composed of a large number of highly diverse cell types with different molecular, anatomical, and functional features. Distinct cellular identities are generated during development under the regulation of intricate genetic programs and manifested through unique combinations of gene expression. Recent advancements in our understanding of the molecular and cellular mechanisms underlying the assembly, function, and pathology of the brain circuitry depend on the invention and ...
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#1Dong-Dong Shi (SJTU: Shanghai Jiao Tong University)
#2Ying-Dan Zhang (SJTU: Shanghai Jiao Tong University)
Last. Zhen Wang (SJTU: Shanghai Jiao Tong University)H-Index: 109
view all 6 authors...
Early-life stress is normally thought of as a major risk for psychiatric disorders, but many researchers have revealed that adversity early in life may enhance stress resilience later in life. Few studies have been performed in rodents to address the possibility that exposure to early-life stress may enhance stress resilience, and the underlying neural mechanisms are far from being understood. Here, we established a "two-hit" stress model in rats by applying two different early-life stress parad...
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#1Thomas Kerloch (French Institute of Health and Medical Research)H-Index: 1
#2Fanny Farrugia (French Institute of Health and Medical Research)H-Index: 2
Last. Hélène Doat (French Institute of Health and Medical Research)H-Index: 1
view all 17 authors...
Despite the central role of Rho GTPases in neuronal development, their functions in adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional maturation of adult-born dentate granule neurons. Interestingly, most of these functions are specific to granule neurons generated during adulthood since the deletion...
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