Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers
Abstract
The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs). CS-NPs (461.2-482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic gum (AG, >250 kDa), or hyaluronic acid (HA, >1000 kDa). Mucoadhesion and cell permeation of QUE were significantly increased by positive charged CS-NPs...
Paper Details
Title
Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers
Published Date
Sep 1, 2021
Journal
Volume
267
Pages
118157 - 118157
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