Eun Suh Kim
Hanyang University
PolysaccharideBiophysicsNuclear chemistrySolubilityNanoparticleControlled releaseChemistryParticle sizeMaterials scienceFucoidanPolyglutamic acidResveratrolAntithromboticAntioxidantCalcium alginateGinsengCatechinChitosanQuercetinFood scienceChemical engineeringChromatographyAntimicrobialBiochemistryTraditional medicineMedicinePharmacology
17Publications
8H-index
156Citations
Publications 17
Newest
#1Eun Suh Kim (Hanyang University)H-Index: 8
#2Da Young Kim (Hanyang University)H-Index: 1
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
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Abstract The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs). CS-NPs (461.2–482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic gum (AG, >250 kDa), or hyaluronic acid (HA, >1000 kDa). Mucoadhesion and cell permeation of QUE were significantly increased by positive charged CS-NPs due to interactions with negatively charge...
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#1Eun Suh Kim (Hanyang University)H-Index: 8
#2Ji Soo Lee (Hanyang University)H-Index: 10
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
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Abstract Background Red ginseng extract (RG), especially ginsenoside Rg1 and Rb1 fractions has been reported to have antithrombotic activities. However, gastric instability and low intestinal permeability are considered to be obstacles to its oral administration. We hypothesized that stability, permeability, and activities of RG might be improved by encapsulation within nanoparticles (NPs) prepared with antithrombotic coating materials. Methods RG-loaded chitosan (CS) NPs (PF-NPs) were prepared ...
2 CitationsSource
#1Eun Suh Kim (Hanyang University)H-Index: 8
#2Da Young Kim (Hanyang University)H-Index: 1
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
view all 4 authors...
Quercetin (QUE)-loaded nanoparticles (QCG-NPs) were fabricated by ionic gelation between chitosan (CS) and gum arabic (GA) at pH 3.5. At constant CS (0.5 mg/mL) and QUE (60 μM) concentrations, QCG-NPs (260–490 nm) were prepared uniformly with 0.8–2.2 mg/mL GA and exhibited high QUE encapsulation efficiency (94.8–98.0%) and sustained QUE release (4.42–8.89% after 8 h). Because of the electrostatic interaction between QCG-NPs and the mucin layer, in vitro mucin and cell adhesion of QUE were signif...
7 CitationsSource
#1Kyung Hyun Lee (Hanyang University)H-Index: 1
#2Ji Soo Lee (Hanyang University)H-Index: 10
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
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Abstract Rosemary extract (RE) was nanoencapsulated with the natural antimicrobial polysaccharide chitosan and γ-poly glutamic acid (γ-PGA) to improve the antimicrobial activity of RE. Three types of RE nanoparticles (RENPs) were generated with different chitosan concentrations (0.1–1.8 mg/mL) and particle sizes (200–600 nm). Nanoencapsulation significantly increased the antimicrobial activity of RE against Bacillus subtilis, and the highest activity was observed for the largest particles, which...
15 CitationsSource
Source
#1Jeong Bin Min (Hanyang University)H-Index: 1
#2Eun Suh Kim (Hanyang University)H-Index: 8
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
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The aim of the study was to encapsulate resveratrol (RV) in trimethyl chitosan (TMC) nanoparticles cross-linked with tripolyphosphate (TPP) and/or alginate to achieve controlled release and improved cellular uptake. TMC (degree of quaternization of 78%) was prepared by reacting purified chitosan with iodomethane. Three types of RV-loaded TMC nanoparticles were prepared: TMC–TPP (TP-NPs), TMC–alginate (TA-NPs), and TMC–alginate–TPP (TAP-NPs). TA-NPs and TAP-NPs showed lower particle size and enca...
10 CitationsSource
#1Hyun Jeong Je (Hanyang University)H-Index: 2
#2Eun Suh Kim (Hanyang University)H-Index: 8
Last. Hyeon Gyu LeeH-Index: 35
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The influences of particle size on the physicochemical, release, and cellular uptake properties of chitosan nanoparticles (CSNPs) were investigated. Ionotropic CSNPs of different sizes (200–1000 nm) loaded with two model core materials (resveratrol or coumarin-6) were prepared using tripolyphosphate and carrageenan as cross-linkers. With an increase of particle size, zeta potential (34.6 ± 0.5 to 51.1 ± 0.9) and entrapment efficiency (14.9 ± 1.4 to 40.9 ± 1.9) of the CSNPs were significantly (p ...
14 CitationsSource
#1Ji-Soo Lee (Hanyang University)H-Index: 13
#2Ji Woon Suh (Hanyang University)H-Index: 2
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
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The mucoadhesive nanoparticles (NPs) for oral delivery of coenzyme Q10 (CoQ10) were prepared using natural mucoadhesive polysaccharides, chitosan (CS), and dextran sulfate sodium salt (DS) in order to improve the solubility, cellular uptake, and thermo- and photostability of CoQ10. CoQ10-loaded NPs were prepared in the range of 340–450 nm with an entrapment efficiency of 60–98%. The mucoadhesiveness and cellular uptake of NPs were evaluated by measuring the amount of mucin adsorbed on NPs and Co...
9 CitationsSource
#1Ji-Soo Lee (Hanyang University)H-Index: 13
#2Da Young Hong (Hanyang University)H-Index: 2
Last. Hyeon Gyu Lee (Hanyang University)H-Index: 35
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Abstract The aims of this study were to improve the water solubility and antimicrobial activity of milk thistle silymarin by nanoencapsulation and to assess the functions of silymarin nanoparticle-containing film as an antimicrobial food-packaging agent. Silymarin nanoparticles were prepared using water-soluble chitosan (WCS) and poly-γ-glutamic acid (γ-PGA). As the WCS and silymarin concentrations increased, particle size and polydispersity index (PDI) significantly increased. Nanoencapsulation...
22 CitationsSource
#1Seul LeeH-Index: 10
#2Eun Suh KimH-Index: 8
Last. Hyeon Gyu LeeH-Index: 35
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1 CitationsSource