Cognitive impairment after focal brain lesions is better predicted by damage to structural than functional network hubs

Significance Hubs are highly connected brain regions that are important for coordinating processing in brain networks and supporting cognition. There are several different methods for characterizing network hubs in gray and white matter, yet it is unclear which of these hub measures identify sites that are most critical for supporting cognition. Here, we use data from two large cohorts of patients with focal brain damage to show that lesions of...