Proceedings of the National Academy of Sciences of the United States of America
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#1Shilei Zhang (UCLA: University of California, Los Angeles)
#2Jingfeng Wang (UCLA: University of California, Los Angeles)
Last. Genhong Cheng (UCLA: University of California, Los Angeles)H-Index: 90
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COVID-19, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has presented a serious risk to global public health. The viral main protease Mpro (also called 3Clpro) encoded by NSP5 is an enzyme essential for viral replication. However, very few host proteins have been experimentally validated as targets of 3Clpro. Here, through bioinformatics analysis of 300 interferon stimulatory genes (ISGs) based on the prediction method NetCorona, we identify RNF20 (Ring Finger Protein 20) as a n...
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#1Silvia Galván-Peña (Harvard University)H-Index: 2
#2Juliette Leon (University of Paris)H-Index: 4
Last. Alicja Piechocka-Trocha (MIT: Massachusetts Institute of Technology)H-Index: 28
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The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We hypothesized that perturbations in FoxP3+ T regulatory cells (Treg), key enforcers of immune homeostasis, contribute to COVID-19 pathology. Cytometric and transcriptomic profiling revealed a distinct Treg phenotype in severe COVID-19 patients, with an increase in Treg proportions and intracellular levels of the lineage-defining transcription factor FoxP3, corre...
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#1Samuel H. Preston (UPenn: University of Pennsylvania)H-Index: 73
#2Yana C Vierboom (MPG: Max Planck Society)H-Index: 2
The Letter by Patrick Heuveline (1) usefully extends our analysis (2) to include the estimated effects … [↵][1]1To whom correspondence may be addressed. Email: vierboom{at}demogr.mpg.de. [1]: #xref-corresp-1-1
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#1Srinivas Chamakuri (BCM: Baylor College of Medicine)H-Index: 5
#2Shuo Lu (BCM: Baylor College of Medicine)H-Index: 1
Last. Jian-Yuan Li (BCM: Baylor College of Medicine)H-Index: 2
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of traditional therapeutic discovery is poorly suited to producing targeted treatments against rapidly evolving viruses. Here, we used an affinity-based screen of 4 billion DNA-encoded molecules en masse to identify a potent class of virus-specific inhibito...
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#1M Ece Kars (Bilkent University)H-Index: 1
#2A Nazlı Başak (Koç University)H-Index: 5
Last. David Neil Cooper (Cardiff University)H-Index: 116
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The construction of population-based variomes has contributed substantially to our understanding of the genetic basis of human inherited disease. Here, we investigated the genetic structure of Turkey from 3,362 unrelated subjects whose whole exomes (n = 2,589) or whole genomes (n = 773) were sequenced to generate a Turkish (TR) Variome that should serve to facilitate disease gene discovery in Turkey. Consistent with the history of present-day Turkey as a crossroads between Europe and Asia, we fo...
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1 CitationsSource
To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for seven passages, but, after 45 d, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed, at day 80,...
3 CitationsSource
#1Heike Klüver (Humboldt University of Berlin)H-Index: 21
#2Felix Hartmann (Humboldt University of Berlin)
Last. Johannes Giesecke (Humboldt University of Berlin)H-Index: 15
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Recent evidence suggests that vaccination hesitancy is too high in many countries to sustainably contain COVID-19. Using a factorial survey experiment administered to 20,500 online respondents in Germany, we assess the effectiveness of three strategies to increase vaccine uptake, namely, providing freedoms, financial remuneration, and vaccination at local doctors. Our results suggest that all three strategies can increase vaccination uptake on the order of two to three percentage points (PP) ove...
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#1J. D. Patterson (UCI: University of California, Irvine)H-Index: 1
#2Murat Aydin (UCI: University of California, Irvine)H-Index: 16
Last. Eric S. Saltzman (UCI: University of California, Irvine)H-Index: 59
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The atmospheric history of molecular hydrogen (H2) from 1852 to 2003 was reconstructed from measurements of firn air collected at Megadunes, Antarctica. The reconstruction shows that H2 levels in the southern hemisphere were roughly constant near 330 parts per billion (ppb; nmol H2 mol-1 air) during the mid to late 1800s. Over the twentieth century, H2 levels rose by about 70% to 550 ppb. The reconstruction shows good agreement with the H2 atmospheric history based on firn air measurements from ...
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#1Inga Geipel (STRI: Smithsonian Tropical Research Institute)H-Index: 9
#2Ella Zoe Lattenkamp (MPG: Max Planck Society)H-Index: 5
Last. Rachel A. Page (STRI: Smithsonian Tropical Research Institute)H-Index: 24
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Tropical ecosystems are known for high species diversity. Adaptations permitting niche differentiation enable species to coexist. Historically, research focused primarily on morphological and behavioral adaptations for foraging, roosting, and other basic ecological factors. Another important factor, however, is differences in sensory capabilities. So far, studies mainly have focused on the output of behavioral strategies of predators and their prey preference. Understanding the coexistence of di...
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