A Systematic Review of Focal Ablative Therapy for Clinically Localised Prostate Cancer in Comparison with Standard Management Options: Limitations of the Available Evidence and Recommendations for Clinical Practice and Further Research

The clinical effectiveness of focal therapy (FT) for localised prostate cancer (PCa) remains controversial.To analyse the evidence base for primary FT for localised PCa via a systematic review (SR) to formulate clinical practice recommendations.A protocol-driven, PRISMA-adhering SR comparing primary FT (sub-total, focal, hemi-gland, or partial ablation) versus standard options (active surveillance [AS], radical prostatectomy [RP], or external...