A longitudinal study using latent curve models of groups with mild cognitive impairment and Alzheimer’s disease

This study explores how mild cognitive impairment (MCI) and Alzheimer’s disease (AD) develop over time. this study involves a new application of latent curve models (LCM) to examine the development trajectory of a healthy, MCI, and AD groups on a series of clinical and neural measures. Multiple-group latent curve models were used to compare the parameters of the trajectories across groups. LCM results showed that a linear functional form of...