Journal of Neuroscience Methods
Papers 9,011
1 page of 902 pages (9,011 results)
#1Dongmin Lee (Korea University)H-Index: 3
#2Hyung Bae Kwon (Johns Hopkins Medicine)H-Index: 20
Oxytocin is a neuropituitary hormone that is involved in a wide range of psychosocial behaviors. Despite its psychophysiological importance as a neuromodulator in the CNS, effective techniques capable of monitoring oxytocin dynamics or testing related behavioral consequences are limited. Along with an explosive advancement in synthetic biology, high-performance genetically-encoded neuromodulator sensors are being developed. Here we comprehensively review the current methodologies available for d...
#1Roy Ben-Shalom (UCSF: University of California, San Francisco)H-Index: 8
#2Alexander Ladd (UCB: University of California, Berkeley)
Last. Kevin J. Bender (UCSF: University of California, San Francisco)H-Index: 26
view all 9 authors...
Abstract null null Background null The membrane potential of individual neurons depends on a large number of interacting biophysical processes operating on spatial-temporal scales spanning several orders of magnitude. The multi-scale nature of these processes dictates that accurate prediction of membrane potentials in specific neurons requires the utilization of detailed simulations. Unfortunately, constraining parameters within biologically detailed neuron models can be difficult, leading to po...
#1Brennan J. Thompson (USU: Utah State University)H-Index: 20
#2Caroline Shugart (USU: Utah State University)
Last. Talin Louder (USU: Utah State University)H-Index: 5
view all 4 authors...
BACKGROUND The psychomotor vigilance task (PVT) is a commonly used test that effectively assesses neurobehavioral alertness. The originally developed PVT is 10 minutes in duration, which presents practical and logistical issues, particularly when administered to large samples or on a repetitive basis. More recently the PVT has been used in both 3- and 5-minute formats. While both of these durations have been shown to be field sensitive to identify impairments from sleep- and fatigue-related inte...
#1Charlotte Moraldo (ETH Zurich: ETH Zurich)
#2Emilie Vuille-dit-Bille (ETH Zurich: ETH Zurich)
Last. Nako Nakatsuka (ETH Zurich: ETH Zurich)H-Index: 12
view all 5 authors...
Abstract null null Chemical biosensors with the capacity to continuously monitor various neurotransmitter dynamics can be powerful tools to understand complex signaling pathways in the brain. However, in vivo detection of neurochemicals is challenging for many reasons such as the rapid release and clearance of neurotransmitters in the extracellular space, or the low target analyte concentrations in a sea of interfering biomolecules. Biosensing platforms with adequate spatiotemporal resolution co...
#1Aundrea Rainwater (UVA: University of Virginia)H-Index: 4
#2Ali D. Güler (UVA: University of Virginia)H-Index: 19
#1Xiao-Tian Liu (CAS: Chinese Academy of Sciences)
view all 3 authors...
Abstract null null Background null Motor handicap is prevalent in patients with traumatic brain injury, but currently. there is a challenging task to prevent the degeneration of motor neurons and to fully recover the. voluntary movement after injury. null null null New method null For the first time, we propose to apply needlestick injuries to the primary motor cortex to create mouse model of voluntary movement deficits. Rotarod test, cylinder test and forepaw grip strength test were used to ass...
#1Naser Sharafkhani (Deakin University)
#2Abbas Z. Kouzani (Deakin University)H-Index: 38
Last. J. O. Orwa (Deakin University)H-Index: 16
view all 7 authors...
Insertion of a microelectrode into the brain to record/stimulate neurons damages neural tissue and blood vessels and initiates the brain's wound healing response. Due to the large difference between the stiffness of neural tissue and microelectrode, brain micromotion also leads to neural tissue damage and associated local immune response. Over time, following implantation, the brain's response to the tissue damage can result in microelectrode failure. Reducing the microelectrode's cross-sectiona...
#1W. Raabe (University of Minnesota)H-Index: 1
#2D. Walk (University of Minnesota)H-Index: 1
Abstract null null Background null In clinical practice, small myelinated sensory fibers conveying pain and other sensations, Aδ-fibers, cannot be examined with available nerve conduction study techniques. null null null New method null Equipment available in clinical neurophysiology laboratories is used to record from human sensory nerves multiple averaged responses to non-painful stimulation of intraepidermal nerves. Ten averaged responses are analyzed in all possible pair combinations with an...
#1Megan Pino (OSU: The Ohio State University)
#2Ranjit Ganguly (OSU: The Ohio State University)H-Index: 4
Last. Vibhor Krishna (OSU: The Ohio State University)H-Index: 20
view all 11 authors...
Abstract null null Background null Longitudinal access to cerebrospinal fluid (CSF) is useful for biomarker discovery in neurological disorders or diseases affecting CSF composition. Here, we aim to test a new method for insertion of a permanent intrathecal catheter, facilitating longitudinal collection of CSF. null null null New Method null We surgically placed a permanent intrathecal catheter into the cisterna magna of anesthetized neonatal piglets. The thecal sac was accessed at the L5-S1 spi...
#1Haoze Chen (NUC: North University of China)
#2Zhijie Zhang (NUC: North University of China)
Last. Fengxiang Wang (NUC: North University of China)
view all 4 authors...
ABSTRACT null null Background null There is growing interest in the neuroscience community in estimating and mapping microscopic properties of brain tissue non-invasively using magnetic resonance measurements. Machine learning methods are actively investigated to predict the signals measured in diffusion magnetic resonance imaging (dMRI). null null null New Method null We applied the neural architecture search (NAS) to train a recurrent neural network to generate a multilayer perceptron to predi...
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