Young adult cognitive ability moderates effects of lifestyle behaviors on brain aging in late midlife: A longitudinal study of cognitive reserve

Background Recent studies have reported significant associations between modifiable lifestyle factors and dementia (Licher et al, 2019; Lourida et al, 2019). We sought to extend those findings by examining whether the effect of lifestyle on brain age, a possible risk factor for dementia, is moderated by one’s level of general cognitive ability (GCA). Additionally, we examined associations between brain aging and mild cognitive impairment (MCI)....