Sean N. Hatton
University of Sydney
PsychiatryInternal medicineNeuropsychologyDiffusion MRIPsychologyTwin studyNeuroscienceCognitionBipolar disorderDepression (differential diagnoses)DiseaseAmygdalaMajor depressive disorderTemporal lobeWhite matterAudiologyNeuroimagingClinical psychologyMedicineSchizophreniaBiologyFractional anisotropy
Publications 87
#1Nils Opel (WWU: University of Münster)H-Index: 28
#2Anbupalam Thalamuthu (UNSW: University of New South Wales)H-Index: 37
Last. Georg Woditsch (WWU: University of Münster)H-Index: 2
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Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced ef...
4 CitationsSource
#1Bader Chaarani (UVM: University of Vermont)H-Index: 12
#2Sage Hahn (UVM: University of Vermont)H-Index: 2
Last. Matthew D. Albaugh (UVM: University of Vermont)H-Index: 21
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The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with...
2 CitationsSource
#1Yi Li (UCSF: University of California, San Francisco)H-Index: 94
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
Last. Sandra A. Brown (UCSD: University of California, San Diego)H-Index: 124
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Importance Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to findings requiring urgent medical intervention. In the case of brain magnetic resonance imaging (MRI), reliable data about the prevalence and significance of IFs in the general population are limited, making it difficult to anticipate, communicate, and manage these findings. Objectives To determine the overall prevalence of IFs in brain MRI in the nonclinical...
#1Bo-yong Park (Inha University)H-Index: 13
#2Sara Larivière (Montreal Neurological Institute and Hospital)H-Index: 11
Last. Boris C. Bernhardt (Montreal Neurological Institute and Hospital)H-Index: 46
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Temporal lobe epilepsy (TLE), a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter pathology in TLE relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically in...
#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...
#1Sophia Frangou (UBC: University of British Columbia)H-Index: 83
#2Amirhossein Modabbernia (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 27
Last. Danai Dima (City University London)H-Index: 26
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Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in corti...
1 CitationsSource
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
#1Dashiell D. Sacks (University of the Sunshine Coast)
#2Jim Lagopoulos (University of the Sunshine Coast)H-Index: 56
Last. Daniel F. Hermens (University of the Sunshine Coast)H-Index: 51
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Abstract The present study investigated differences in white matter (WM) integrity between 96 young people with affective and/or psychotic symptoms classified at an early stage of mental disorder (i.e. ‘attenuated syndrome’; stage 1b), 85 young people classified at a more advanced stage of mental disorder (i.e. ‘discrete disorder’; stage 2), and 81 demographically matched healthy controls using diffusion tensor imaging. The relationship between WM integrity (indexed by fractional anisotropy; FA)...
#1Jeanne Leerssen (KNAW: Royal Netherlands Academy of Arts and Sciences)H-Index: 5
#2Tessa F. Blanken (KNAW: Royal Netherlands Academy of Arts and Sciences)H-Index: 12
Last. Eus J.W. Van Someren (KNAW: Royal Netherlands Academy of Arts and Sciences)H-Index: 66
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It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts...
15 CitationsSource
#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. William S. KremenH-Index: 70
view all 6 authors...