Hydroxybutyl Chitosan Centered Biocomposites for Potential Curative Applications: A Critical Review.
Published on Mar 23, 2020in Biomacromolecules6.092
· DOI :10.1021/ACS.BIOMAC.0C00071
Chitosan (CS), a natural biopolymer, has been extensively explored for multiple applications including tissue engineering, gene therapy, bio-imaging and sewage treatment due to its abundant availability, intrinsic biocompatibility, biodegradability and tunable biological properties. Nevertheless, the actual use of CS is limited on account of its water-insolubility in physiological circumstances, which could be optimized by chemical modifications via active side groups. Etherification is one of the most widespread-used reactions to obtain water-soluble CS derivatives, such as hydroxybutyl CS (HBC). Hydroxybutyl CS (HBC), synthesized by grafting hydroxybutyl groups to the functional hydroxyl and amino groups of CS skeleton, has been demonstrated to possess superior biological properties over CS, especially satisfactory water solubility in neutral condition and reversible stimulus-responsive against the external thermo. Meanwhile, the unique characteristics of thermal sensitive "sol-gel" and "sol-micelle" transition have gained tremendous attention, which differ in heterogeneously and homogeneously synthesized HBC. Herein, we discuss the synthesis (heterogeneously and homogeneously) of HBC, favorable physiochemical properties of HBC and HBC-centered biocomposites in a range of formulations or dosage forms such as sponges, gels, nanoparticles, nanofibers and films. Meanwhile, we summarize the potential bio-applications and trends of HBC and HBC centered biocomposites and offer our perspectives on the plausible advances in this field in near future.