Biomacromolecules
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#1Jinyuan Hu (Jiangnan University)
#2Jie Wang (Jiangnan University)
Last. Fei Xu (Jiangnan University)H-Index: 18
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As an important component of biomaterials, collagen provides three-dimensional scaffolds and biological cues for cell adhesion and proliferation in tissue engineering. Recombinant collagen-like proteins, which were initially discovered in Streptococcus pyogenes and produced in heterologous hosts, have been chemically and genetically engineered for biomaterial applications. However, existing collagen-like proteins do not form gels, limiting their utility as biomaterials. Here, we present a series...
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#1Zhimin Dong (NBU: Ningbo University)
#2Yushuang Miao (NBU: Ningbo University)
Last. Zongbao Wang (NBU: Ningbo University)H-Index: 14
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PGA and P(GA-co-LA) fibers applied as surgical sutures strongly depend on their microstructure. The structural evolution in both the relaxed and tensioned states during heat-setting after hot stretching, which included heating and postannealing, was investigated using in situ WAXD/SAXS and DSC techniques. We found that the fibers of both PGA and P(GA-co-LA) with 8% LA content under the relaxed state were more advantageous than the fibers under the tensioned state indicated by the larger crystall...
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#1Marta Díaz-Caballero (Autonomous University of Barcelona)H-Index: 4
#2Susanna Navarro (Autonomous University of Barcelona)H-Index: 17
Last. Salvador Ventura (Autonomous University of Barcelona)H-Index: 55
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Protein amyloid nanofibers provide a biocompatible platform for the development of functional nanomaterials. However, the functionalities generated up to date are still limited. Typical building blocks correspond to aggregation-prone proteins and peptides, which must be modified by complex and expensive reactions post-assembly. There is high interest in researching alternative strategies to tailor amyloid-based nanostructures' functionality on demand. In the present study, the biotin-streptavidi...
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#2Jenny Johansson (Research Institutes of Sweden)H-Index: 14
Last. Joakim Håkansson (University of Gothenburg)H-Index: 16
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Cellulose nanofibrils (CNFs) were obtained by applying a chemical pretreatment consisting of autoclaving the pulp fibers in sodium hydroxide, combined with 2,2,6,6-tetramethylpiperidinyl-1-oxyl-mediated oxidation. Three levels of sodium hypochlorite were applied (2.5, 3.8, and 6.0 mmol/g) to obtain CNF qualities (CNF_2.5, CNF_3.8, and CNF_6.0) with varying content of carboxyl groups, that is, 1036, 1285, and 1593 μmol/g cellulose. The cytotoxicity and skin irritation potential (indirect tests) o...
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#1Panpan Song (Ocean University of China)
#2Nannan Song (Ocean University of China)
Last. Xia Zhao (Ocean University of China)
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Glioblastoma (GBM) is a fatal brain tumor with poor prognosis. Blood-brain barrier (BBB) prevents the effective delivery of chemotherapeutic agents to GBM. Herein, we developed a pH/reduction-sensitive carboxymethyl chitosan nanogel (CMCSN) modified by targeting peptide angiopep-2 (ANG) and loaded with doxorubicin (DOX). The multifunctional nanogel (DOX-ANG-CMCSN) exhibited good pH and reduction sensitivity, ideal stability, and biocompatibility. Its hydrodynamic diameter was 190 nm, drug loadin...
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#1Leonid I. Kaberov (CAS: Academy of Sciences of the Czech Republic)H-Index: 6
#2Zhansaya Kaberova (CAS: Academy of Sciences of the Czech Republic)H-Index: 1
Last. Daniel JirákH-Index: 21
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The use of fluorinated contrast agents in magnetic resonance imaging (MRI) facilitates improved image quality due to the negligible amount of endogenous fluorine atoms in the body. In this work, we present a comprehensive study of the influence of the amphiphilic polymer structure and composition on its applicability as contrast agents in 19F MRI. Three series of novel fluorine-containing poly(2-oxazoline) copolymers and terpolymers, hydrophilic-fluorophilic, hydrophilic-lipophilic-fluorophilic,...
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#1Tanja Thomsen (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 1
#2Regina Reissmann (University of Bern)
Last. Harm-Anton Klok (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 69
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Cells are attractive as carriers that can help to enhance control over the biodistribution of polymer nanomedicines. One strategy to use cells as carriers is based on the cell surface immobilization of the nanoparticle cargo. While a range of strategies can be used to immobilize nanoparticles on cell surfaces, only limited effort has been made to investigate the effect of these surface modification chemistries on cell viability and functional properties. This study has explored seven different a...
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#1Huihui Xie (SCUT: South China University of Technology)
#2Hui Zhang (SCUT: South China University of Technology)H-Index: 8
Last. Shiyu Fu (SCUT: South China University of Technology)H-Index: 23
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Lignin/tannin/ZnONP composite coatings were designed for paper-based green packaging. Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating. Prepolymerization improved the physical properties of coatings at high lignin contents. The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared...
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#1Yota Okuno (Kyoto University)H-Index: 1
#2Tomoki Nishimura (Shinshu University)
Last. Kazunari Akiyoshi (Kyoto University)H-Index: 69
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Solute-permeable polymer vesicles are structural compartments for nanoreactors/nanofactories in the context of drug delivery and artificial cells. We previously proposed design guidelines for polymers that form solute-permeable vesicles, yet we did not provide enough experimental verification. In addition, the fact that there is no clear factor for identifying permeable solutes necessitates extensive trial and error. Herein, we report solute-permeable polymer vesicles based on an amphiphilic cop...
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#1Haonan Sun (NKU: Nankai University)H-Index: 2
#2Yunjian Yu (NKU: Nankai University)H-Index: 8
Last. Xinge Zhang (NKU: Nankai University)H-Index: 30
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Antibiotics are currently first-line therapy for bacterial infections. However, the curative effect of antibiotic remedies is limited due to increasingly prevalent bacterial resistance. The strategy to reverse intrinsic acquired drug resistance presents a promising option for reinvigorating antibiotic therapy. Here, we developed a β-lactamase-inhibiting macromolecule composed of benzoxaborole and dextran for precise transport of β-lactam antibiotics to strains overexpressing β-lactamase. Benzoxa...
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