Papers 9,014
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#1Kelli A. Stockmal (USM: University of Southern Mississippi)H-Index: 4
#2Latoyia P Downs (USM: University of Southern Mississippi)
Last. Sarah E. Morgan (USM: University of Southern Mississippi)H-Index: 24
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The black-legged tick (Ixodes scapularis) is the primary vector for bacteria that cause Lyme disease (Borrelia burgdorferi), where numerous glycosylated tick proteins are involved at the interface of vector-host-pathogen interactions. Reducing the expression of key tick proteins, such as selenoprotein K (SelK), through RNA interference is a promising approach to reduce pathogen transmission, but efficient delivery of nucleic acids to arthropods has proven challenging. While cationic glycopolymer...
#1Charng-Yu Lin (Purdue University West Lafayette)
#2Carly M. Battistoni (Purdue University West Lafayette)H-Index: 1
Last. Julie C. Liu (Purdue University West Lafayette)H-Index: 19
view all 3 authors...
Disulfide-cross-linked hydrogels have been widely used for biological applications because of their degradability in response to redox stimuli. However, degradability often depends on polymer concentration, which also influences the hydrogel mechanical properties such as the initial stiffness. Here, we describe a one-pot cross-linking approach utilizing both a thiol-ene reaction through a Michael pathway with divinyl sulfone (DVS) to form non-reducible thioether bonds and thiol oxidation promote...
#1Otavio Augusto Titton Dias (University of Toronto)H-Index: 8
#2Samir K. Konar (University of Toronto)H-Index: 20
Last. Mohini Sain (University of Toronto)H-Index: 69
view all 8 authors...
Regioselectively substituted nanocellulose was synthesized by protecting the primary hydroxyl group. Herein, we took advantage of the different reactivities of primary and secondary hydroxyl groups to graft large capping structures. This study mainly focuses on regioselective installation of trityl protecting groups on nanocellulose chains. The elemental analysis and nuclear magnetic resonance spectroscopy of regioselectively substituted nanofibrillated cellulose (NFC) suggested that the trityl ...
#1Zaifu Lin (XMU: Xiamen University)H-Index: 5
#2Yanru Li (XMU: Xiamen University)H-Index: 2
Last. Xiangyang Liu (NUS: National University of Singapore)H-Index: 70
view all 8 authors...
Microneedles (MNs) have attracted considerable attention in the pharmaceutical field as a minimally invasive delivery alternative to hypodermic needles. Current material systems of MNs have gradually shifted from metals, ceramics, and silicon to polymer in consideration of toughness and drug loading capacity. Silk fibroin (SF) is considered one of the most promising alternatives because it combines the ability to maintain the activity of biomolecules, adjustable mechanical strength, and excellen...
#1Hamideh Basiri (UT: University of Tehran)H-Index: 1
#2Seyed Sepehr Mohseni (UT: University of Tehran)H-Index: 1
Last. Eugenia Kumacheva (University of Toronto)H-Index: 87
view all 7 authors...
Monitoring the supply of vascular endothelial growth factor (VEGF) to ischemic tissues provides information on its biodistribution and delivery to meet the requirements of therapeutic angiogenesis and tissue engineering applications. We herein report the use of microfluidically generated microgels containing VEGF-conjugated fluorescent carbon dots (CDs) (VEGF-CDs), a gelatin-phenol conjugate, and silk fibroin for imaging-monitored tracking of VEGF delivery to ischemic muscles. An in vitro releas...
#1Zhiyuan Fan (UCI: University of California, Irvine)
#2Sharon Jan (UCI: University of California, Irvine)H-Index: 2
Last. Zhibin GuanH-Index: 63
view all 7 authors...
Vaccination has been playing an important role in treating both infectious and cancerous diseases. Nevertheless, many diseases still lack proper vaccines due to the difficulty to generate sufficient amounts of antigen-specific antibodies or T cells. Adjuvants provide an important route to improve and direct immune responses. However, there are few adjuvants approved clinically and many of them lack the clear structure/adjuvanticity relationship. Here, we synthesized and evaluated a series of den...
#1Chuchu Chen (NFU: Nanjing Forestry University)H-Index: 19
#2Wang Yiren (NFU: Nanjing Forestry University)H-Index: 3
Last. Yongcan Jin (NFU: Nanjing Forestry University)H-Index: 26
view all 8 authors...
The purpose of this research is to develop strong and tough wood-based hydrogels, which are reinforced by an aligned cellulosic wood skeleton. The hypothesis is that improved interfacial interaction between the wood cell wall and a polymer is of great importance for improving the mechanical performance. To this end, a facile and green approach, called ultraviolet (UV) grafting, was performed on the polyacrylamide (PAM)-infiltrated wood skeleton without using initiators. An important finding was ...
#1Romy A. Dop (University of Liverpool)
#2Daniel R. Neill (University of Liverpool)H-Index: 19
Last. Tom Hasell (University of Liverpool)H-Index: 46
view all 3 authors...
Inverse vulcanization is a bulk polymerization method for synthesizing high sulfur content polymers from elemental sulfur, a byproduct of the petrochemical industry, with vinylic comonomers. There is growing interest in polysulfides as novel antimicrobial agents due to the antimicrobial activity of natural polysulfides found in garlic and onions (Tsao et al. J. Antimicrob. Chemother. 2001, 47, 665-670). Herein, we report the antibacterial properties of several inverse vulcanized polymers against...
#1Dongyun Kim (SKKU: Sungkyunkwan University)H-Index: 2
#2Hanjun Hwangbo (SKKU: Sungkyunkwan University)H-Index: 2
Last. GeunHyung Kim (SKKU: Sungkyunkwan University)H-Index: 51
view all 3 authors...
The skeletal muscle tissue comprises a hierarchical fibrous structure with fully aligned myofibers. To obtain a unique aligned engineering construct for regenerating muscle tissue, we adopted a submerged bioprinting process. Here, 3 wt % collagen and 6 wt % alginate solutions were used as a matrix cell-encapsulating bioink and supporting solution in the printing bath, respectively. By manipulating the processing parameters (various alginate weight fractions in the bath, nozzle moving speed, and ...
#1Robin Rajan (JAIST: Japan Advanced Institute of Science and Technology)H-Index: 9
#2Nishant Kumar (JAIST: Japan Advanced Institute of Science and Technology)H-Index: 1
Last. Kazuaki Matsumura (JAIST: Japan Advanced Institute of Science and Technology)H-Index: 27
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Freezing-induced damage to proteins, through osmotic stress and ice recrystallization, during protein processing and long-term storage is a serious concern and may lead to loss of protein activity owing to denaturation. In this study, graft copolymers composed of a cryoprotective polymer (capable of preventing osmotic stress) and poly(vinyl alcohol) (PVA; known for its high ice recrystallization inhibition (IRI) property) were developed. The polymers had high IRI activity, albeit slightly lower ...
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