Ya Liu
Ocean University of China
Self-healing hydrogelsCytotoxicityBiophysicsNuclear chemistryNanoparticleNanotechnologyNanocarriersChemistryPolymer chemistryMaterials scienceIn vivoOral administrationBiocompatibilityChitosanDrug deliveryWound healingChemical engineeringChromatographyCancer researchBiochemistryMedicineZeta potentialPharmacology
56Publications
21H-index
1,056Citations
Publications 56
Newest
#1Ying-Xia Yao (Ocean University of China)H-Index: 1
#2Andi Zhang (Ocean University of China)H-Index: 2
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 5 authors...
Acute and chronic wounds can cause severe physical trauma to patients and also result in an immense socio-economic burden. Thus, wound management has attracted increasing attention in recent years. However, burn wound management is still a major challenge in wound management. Autografts are often considered the gold-standard for burn care, but their application is limited by many factors. Hence, ideal burn dressings and skin substitute dressings are desirable. With the development of biomaterial...
Source
#1Mengjie Sun (Ocean University of China)H-Index: 6
#2Di Qin (Ocean University of China)H-Index: 2
Last. Ya Liu (Ocean University of China)H-Index: 21
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Allergic rhinitis (AR), histamine-mediated upper airway inflammatory disorder, is characterized by sneezing, itching, airway hyperreactivity, etc. Though it is clinically well-managed by non-invasive inhaled antihistamines, for example, ketotifen (KT, histamine release inhibitor) and cetirizine (CTZ, histamine receptor antagonist), inherent defects of short mucosal in situ retention, frequent administration resulting in irritation to mucosa, and lack of target-specific sequential release of dual...
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#1Meiping Tian (Ocean University of China)H-Index: 6
#2Andi Zhang (Ocean University of China)H-Index: 2
Last. Ya Liu (Ocean University of China)H-Index: 21
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Abstract Hydrogels have gained great attentions as wound dressing. Binding to the tissue and preventing wound infection were the basic requirements for an “ideal dressing”. We employed L-DOPA and e-Poly-L-lysine to modify thermo-sensitive hydroxybutyl chitosan (HBC) to obtain (L-DOPA) - (e-Poly-L-lysine)-HBC hydrogels (eLHBC). The eLHBC exhibited an almost 1.5 fold (P
3 CitationsSource
#1Zhenwei Deng (Ocean University of China)H-Index: 1
#2Cong-Shan Yuan (Ocean University of China)H-Index: 1
Last. Ya Liu (Ocean University of China)H-Index: 21
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Abstract In recent years, with the continuous development of cancer immunotherapy, the strategy of human beings against cancer has undergone tremendous changes. Among them, immune checkpoint inhibitors based on the immune "brake" mechanism, as an indispensable part of immunotherapy, have brought new dawn to cancer treatment. Humans have developed a variety of monoclonal antibodies against CTLA-4 and PD-1/PD-L1, which have shown significant therapeutic effects on various cancers, especially melan...
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Allergy, IgE-mediated inflammatory disorders including allergic rhinitis, asthma, and conjunctivitis, affects billions of people worldwide. Conventional means of allergy management include allergen avoidance, pharmacotherapy, and emerging therapies. Among them, chemotherapeutant intake via oral, intravenous, and intranasal routes is always the most common mean. Although current pharmacotherapy exhibit splendid anti-allergic effects, short in situ retention, low bioavailability, and systemic side...
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#1Cong-Shan Yuan (Ocean University of China)H-Index: 1
#2Zhenwei Deng (Ocean University of China)H-Index: 1
Last. Ya Liu (Ocean University of China)H-Index: 21
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Abstract The past several years have witnessed the blooming of emerging immunotherapy, as well as their therapeutic potential in remodeling the immune system. Nevertheless, with the development of biological mechanisms in oncology, it has been demonstrated that hypoxic tumor microenvironment (TME) seriously impairs the therapeutic outcomes of immunotherapy. Hypoxia, caused by Warburg effect and insufficient oxygen delivery, has been considered as a primary construction element of TME and drawn t...
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#1Ya Liu (Ocean University of China)H-Index: 21
#2Mengjie Sun (Ocean University of China)H-Index: 6
Last. Hao WangH-Index: 1
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2 CitationsSource
#1Andi Zhang (Ocean University of China)H-Index: 2
#2Ya Liu (Ocean University of China)H-Index: 21
Last. Xiguang Chen (Ocean University of China)H-Index: 61
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Abstract Wound management has attracted significant interest in view of the broad demand market. Dressings are playing crucial roles in wounds management because they can protect the wound from external infection, and accelerate the healing process. Among the various available dressing materials, hydrogels have appealed increasing attention for their tunable chemical, physical and biological properties, and three-dimensional cross-linked polymer networks which can absorb and retain large amount ...
16 CitationsSource
#1Zhenwei DengH-Index: 1
#2Ting WangH-Index: 5
Last. Ya LiuH-Index: 1
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Marine-derived chitosan has been widely examined for its use in developing biomedical materials. Not only is it non-toxic, biocompatible, and degradable, it has also shown unique antimicrobial properties. The antimicrobial properties of chitosan are restricted by neutral and physiological conditions because it is insoluble in water and its pKa values is 6.5. One solution to this problem is to graft chemically modified groups onto the backbone of chitosan. The aim of this paper is to review the m...
9 CitationsSource
#1Cong-Shan Yuan (Ocean University of China)H-Index: 1
#2Ya Liu (Ocean University of China)H-Index: 21
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 5 authors...
Immunomodulatory therapeutics, which is conducive to overcoming tumor tolerance and restoring normal immune responses, has been proposed as a promising approach for enhanced cancer therapy and clin...
7 CitationsSource