Mengjie Sun
Ocean University of China
PolysaccharideHistamine H1 receptorSelf-healing hydrogelsHistamineUltimate tensile strengthNanomaterialsNuclear chemistrySolubilityNanoparticleBiodegradationMolar mass distributionHistamine receptorControlled releaseNanotechnologyTranscellularIntensive care medicineShrinkageBioavailabilityNanocarriersAqueous solutionLiposomeChemistryParticle sizeLower critical solution temperatureMaterials scienceCrystallizationRaw materialAllergyPsychological interventionAsthmaDemineralizationAntagonistLysozymeOral administrationIrritationBiocompatibilityPortunus trituberculatusSelf-healingCurcuminBiopolymerCetirizineChitosanDrug deliveryAntibacterial activityUreaKetotifenVinyl alcoholDeoxycholic acidIntestinal permeabilityIntestinal epitheliumDrug accumulationCancer therapyDelivery systemBiological propertyDrug release rateElectrostatic adsorptionWound dressingPolymer coatingDemand marketSelf assembledOral retinoidMechanical propertyOral routeWound managementAllergen avoidanceDrug releaseComputer scienceChemical engineeringTissue engineeringPharmacotherapyCancer researchColorectal cancerMucous membrane of noseParacellular transportMedicineDosage formNasal administrationImmune systemNanofiberPharmacologyToughness
12Publications
6H-index
115Citations
Publications 12
Newest
#1Mengjie Sun (Ocean University of China)H-Index: 6
#2Di Qin (Ocean University of China)H-Index: 2
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 5 authors...
Allergic rhinitis (AR), histamine-mediated upper airway inflammatory disorder, is characterized by sneezing, itching, airway hyperreactivity, etc. Though it is clinically well-managed by non-invasive inhaled antihistamines, for example, ketotifen (KT, histamine release inhibitor) and cetirizine (CTZ, histamine receptor antagonist), inherent defects of short mucosal in situ retention, frequent administration resulting in irritation to mucosa, and lack of target-specific sequential release of dual...
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Allergy, IgE-mediated inflammatory disorders including allergic rhinitis, asthma, and conjunctivitis, affects billions of people worldwide. Conventional means of allergy management include allergen avoidance, pharmacotherapy, and emerging therapies. Among them, chemotherapeutant intake via oral, intravenous, and intranasal routes is always the most common mean. Although current pharmacotherapy exhibit splendid anti-allergic effects, short in situ retention, low bioavailability, and systemic side...
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#1Ya Liu (Ocean University of China)H-Index: 21
#2Mengjie Sun (Ocean University of China)H-Index: 6
Last. Hao WangH-Index: 1
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#1Andi Zhang (Ocean University of China)H-Index: 2
#2Ya Liu (Ocean University of China)H-Index: 21
Last. Xiguang Chen (Ocean University of China)H-Index: 61
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Abstract Wound management has attracted significant interest in view of the broad demand market. Dressings are playing crucial roles in wounds management because they can protect the wound from external infection, and accelerate the healing process. Among the various available dressing materials, hydrogels have appealed increasing attention for their tunable chemical, physical and biological properties, and three-dimensional cross-linked polymer networks which can absorb and retain large amount ...
8 CitationsSource
#1Cong-Shan Yuan (Ocean University of China)H-Index: 1
#2Ya Liu (Ocean University of China)H-Index: 21
Last. Xiguang Chen (Ocean University of China)H-Index: 61
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Immunomodulatory therapeutics, which is conducive to overcoming tumor tolerance and restoring normal immune responses, has been proposed as a promising approach for enhanced cancer therapy and clin...
4 CitationsSource
#1Xuqian Lang (Ocean University of China)H-Index: 7
#2Ting Wang (Ocean University of China)H-Index: 5
Last. Ya Liu (Ocean University of China)H-Index: 21
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The oral drug administration was convenient and comfortable route for patients. Nevertheless, the oral uptake efficiency of many therapeutic agents was limited by physiological barriers of the gastrointestinal (GI) tract. This review summarized the challenges toward the oral delivery systems including instability and poor permeability in gastrointestinal environment. The transcellular and paracellular transport were main pathways of nanocarriers across intestinal epithelium. Chitosan is a nature...
23 CitationsSource
#1Mengjie Sun (Ocean University of China)H-Index: 6
#2Ting Wang (Ocean University of China)H-Index: 5
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 5 authors...
Chitosan (CS), a natural biopolymer, has been extensively explored for multiple applications including tissue engineering, gene therapy, bio-imaging and sewage treatment due to its abundant availability, intrinsic biocompatibility, biodegradability and tunable biological properties. Nevertheless, the actual use of CS is limited on account of its water-insolubility in physiological circumstances, which could be optimized by chemical modifications via active side groups. Etherification is one of t...
4 CitationsSource
#1Liang Huang (Ocean University of China)H-Index: 5
#2Shichao Bi (Ocean University of China)H-Index: 9
Last. Xiguang Chen (Ocean University of China)H-Index: 61
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Abstract The effect of NaOH/urea solution freeze-thaw pretreatment to the chitosan of purity and the degree of deacetylation from the crab shell was examined. Higher purity chitosan (CS1) was prepared. On this basis, the raw materials after the first demineralization were pretreated with NaOH/urea solution freeze-thaw under different freeze-thaw situations. The produced chitosans (CS1-CS4) were characterized in the ash content, solubility, protein content, degree of deacetylation, viscosity aver...
6 CitationsSource
#1Shichao Bi (Ocean University of China)H-Index: 9
#2Jianhui Pang (Ocean University of China)H-Index: 9
Last. Xiguang Chen (Ocean University of China)H-Index: 61
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Abstract Biocompatibility and mechanical properties have always been important indicators for the application of hydrogel materials in tissue engineering. In this work, a high strength and toughness chitosan-poly (vinyl alcohol) (PVA) DN (double network) hydrogel based on multiple hydrogen bonding interactions was prepared by applying the simple freezing-heating alternate treatment to the chitosan-PVA alkaline solution. The PVA first network was prepared by freeze crystallization, and the chitos...
14 CitationsSource
#1Ting Wang (Ocean University of China)H-Index: 5
#2Fangqin Wang (Ocean University of China)H-Index: 3
Last. Ya Liu (Ocean University of China)H-Index: 21
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Abstract Colorectal cancer (CRC) is a prevalent and fatal cancer. Oral administration provided the potential for in situ treatment of the colorectal cancer. However, drugs couldn't be well-absorbed mainly due to its degradation in the gastric area and poor intestinal permeability. In this study, we synthesized deoxycholic acid and hydroxybutyl decorated chitosan nanoparticles (DAHBC NPs) as oral curcumin (CUR) delivery system for colorectal cancer treatment. DAHBC with lower critical solution te...
1 CitationsSource