Eight-year outcomes of a phase III randomized trial of conventional versus hypofractionated high-dose intensity modulated radiotherapy for prostate cancer (CRUK/06/016): Update from the CHHiP Trial

Published on Feb 19, 2020in Journal of Clinical Oncology32.956
路 DOI :10.1200/JCO.2020.38.6_SUPPL.325
David P. Dearnaley108
Estimated H-index: 108
(The Royal Marsden NHS Foundation Trust),
Clare Griffin15
Estimated H-index: 15
(ICR: Institute of Cancer Research)
+ 14 AuthorsEmma Hall57
Estimated H-index: 57
(ICR: Institute of Cancer Research)
Sources
Abstract
325Background: CHHiP is a non-inferiority trial to determine efficacy and safety of hypofractionated radiotherapy for localised prostate cancer (PCa). Five year results indicated that moderate hypo...
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External beam radiotherapy remains the primary treatment modality for localized prostate cancer. The radiobiology of prostate carcinoma lends itself to hypofractionation, with recent studies showing good outcomes with shorter treatment schedules. However, the ability to accurately deliver hypofractionated treatment is limited by current image-guided techniques. Magnetic resonance imaging is the main diagnostic tool for localized prostate cancer and its use in the therapeutic setting offers anato...
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#2Oscar Lilleby (UCPH: University of Copenhagen)H-Index: 1
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Prostate cancer (PCa) is the most common noncutaneous solid organ malignancy among men worldwide. Radiation therapy is a standard of care treatment option that has historically been delivered in the form of small daily doses of radiation over the span of multiple weeks. PCa appears to have a unique sensitivity to higher doses of radiation per fraction, rendering it susceptible to abbreviated forms of treatment. Stereotactic body radiation therapy (SBRT) and high-dose-rate brachytherapy (HDRBT) a...
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