Clare Griffin
Institute of Cancer Research
Internal medicineRadiologyUrologySurgeryOncologyRandomized controlled trialPhysical therapyMedical physicsClinical endpointProstateMastectomyProstate cancerBreast reconstructionHypofractionated RadiotherapyBreast radiotherapyToxicityNuclear medicineRadiation therapyBreast cancerClinical trialMedicineDosimetryImage-guided radiation therapy
Publications 68
#1Christopher M. Nutting (The Royal Marsden NHS Foundation Trust)H-Index: 73
#2Clare Griffin (ICR: Institute of Cancer Research)H-Index: 15
Last. Amen Sibtain (St Bartholomew's Hospital)H-Index: 2
view all 30 authors...
BACKGROUND Radical (chemo)radiotherapy offers potentially curative treatment for patients with locally advanced laryngeal or hypopharyngeal cancer. We aimed to show that dose-escalated intensity-modulated radiotherapy (DE-IMRT) improved locoregional control. METHODS We performed a phase III open-label randomised controlled trial in patients with laryngeal or hypopharyngeal cancer (AJCC III-IVa/b, TNM 7). Patients were randomised (1:1) to DE-IMRT or standard dose IMRT (ST-IMRT) using a minimisati...
#1Shaista Hafeez (The Royal Marsden NHS Foundation Trust)H-Index: 15
#2Rebecca Lewis (ICR: Institute of Cancer Research)H-Index: 16
Last. Robert Huddart (The Royal Marsden NHS Foundation Trust)H-Index: 82
view all 5 authors...
#2Amanda Webster (Mount Vernon Hospital)H-Index: 3
Introduction Daily radiotherapy delivered with radiosensitisation offers patients with muscle invasive bladder cancer (MIBC) comparable outcomes to cystectomy with functional organ preservation. Most recurrences following radiotherapy occur within the bladder. Increasing the delivered radiotherapy dose to the tumour may further improve local control. Developments in image-guided radiotherapy have allowed bladder tumour-focused ‘plan of the day’ radiotherapy delivery. We aim to test within a rand...
•PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation.•Unfavourable intermediate/high risk and bulky local disease are most likely to benefit.•Functional MRI imaging is used to select patients for different types of dose escalation.•HDR brachytherapy or focal dose escalation with IMRT are used as options.•Training and support is provided to reduce variations of contouring and radiotherapy planning.•The trial is recruiting patients in 38 radiotherapy centres ...
#1Agnieszka Lemanska (RMIT: RMIT University)H-Index: 6
#2Rachel Byford (University of Oxford)H-Index: 6
Last. Sara Faithfull (RMIT: RMIT University)H-Index: 29
view all 11 authors...
Randomised controlled trials (RCTs) are the gold standard for evidence-based practice. However, RCTs can have limitations. For example, translation of findings into practice can be limited by design features, such as inclusion criteria, not accurately reflecting clinical populations. In addition, it is expensive to recruit and follow-up participants in RCTs. Linkage with routinely collected data could offer a cost-effective way to enhance the conduct and generalisability of RCTs. The aim of this...
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