Multi-domain neurocognitive classification of primary brain tumor patients prior to radiotherapy on a prospective clinical trial.

Published on Jan 1, 2020in Journal of Neuro-oncology3.267
· DOI :10.1007/S11060-019-03353-2
Roshan Karunamuni15
Estimated H-index: 15
(UCSD: University of California, San Diego),
Kathryn R. Tringale11
Estimated H-index: 11
(UCSD: University of California, San Diego)
+ 7 AuthorsJona A. Hattangadi-Gluth23
Estimated H-index: 23
(UCSD: University of California, San Diego)
Sources
Abstract
Introduction We investigated multi-domain baseline neurocognition of primary brain tumor patients prior to radiotherapy (RT), including clinical predictors of function and association between pre-RT and post-RT impairment on a prospective trial.
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Glioma comprises the vast majority of all malignant primary brain tumors.1 These tumors often disrupt cerebral function through direct mechanisms such as destruction of brain tissue, as well as more indirect means, including compression, displacement, and ischemia.2 As a result, most patients exhibit some impairment of neurocognitive function (NCF), even early in the disease course.3,4 However, when compared with patients with acute lesions related to stroke or trauma, individuals with brain tum...
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