Journal of Neuro-oncology
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#1Tanyeri Barak (Yale University)H-Index: 5
#2Shaurey Vetsa (Yale University)
Last. Evan Gorelick (Yale University)
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While adjuvant treatment regimens have been modified for older patients with glioblastoma (GBM), surgical strategies have not been tailored. Clinical data of 48 consecutive patients aged 70 years or older, who underwent surgical resection for GBM with intraoperative ultrasonography (IoUS) alone or combination with intraoperative MRI (IoMRI) at Yale New Haven Hospital were retrospectively reviewed. Variables were analyzed, and comparative analyses were performed. The addition of IoMRI was not sup...
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#1Jordina Rincon-Torroella (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 13
#2Harmon Khela (JHUSOM: Johns Hopkins University School of Medicine)
Last. Chetan Bettegowda (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 48
view all 4 authors...
Despite advances in modern medicine, brain tumor patients are still monitored purely by clinical evaluation and imaging. Traditionally, invasive strategies such as open or stereotactic biopsies have been used to confirm the etiology of clinical and imaging changes. Liquid biopsies can enable physicians to noninvasively analyze the evolution of a tumor and a patient’s response to specific treatments. However, as a consequence of biology and the current limitations in detection methods, no blood o...
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#1Shelly Wang (Boston Children's Hospital)H-Index: 9
#2Matthew Z. Sun (UCLA: University of California, Los Angeles)H-Index: 2
Last. Christina M. Lockwood (Seattle Children's)H-Index: 24
view all 15 authors...
Purpose null Desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) are classified together as grade I neuronal and mixed neuronal-glial tumor of the central nervous system by the World Health Organization (WHO). These tumors are rare and have not been well characterized in terms of clinical outcomes. We aimed to identify clinical predictors of mortality and tumor recurrence/progression by performing an individual patient data meta-analysis (IPDMA) of the literat...
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#1Victor M. Lu (UM: University of Miami)H-Index: 3
#2Evan Luther (UM: University of Miami)H-Index: 9
Last. Michael E. Ivan (UM: University of Miami)H-Index: 25
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Pineal parenchymal tumors of intermediate differentiation (PPTID) are a rare group of pineal parenchymal tumors classified by histology as either World Health Organization (WHO) Grades 2 or 3. The rarity of these tumors in adults has left a number of clinical management questions open. Correspondingly, the aim of this study was to aggregate a large PPTID cohort with sufficient statistical power from a large national cancer database to analyze prognostic parameters. All PPTID patients aged over 1...
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#1Nitesh V Patel (Lenox Hill Hospital)H-Index: 10
#2Tamika Wong (Lenox Hill Hospital)H-Index: 3
Last. Dimitre G. Stefanov (The Feinstein Institute for Medical Research)H-Index: 1
view all 16 authors...
Pre-clinical evidence suggests bevacizumab (BV) depletes the GBM peri-vascular cancer-stem cell niche. This phase I/II study assesses the safety and efficacy of repeated doses of superselective intra-arterial cerebral infusion (SIACI) of BV after blood–brain barrier disruption (BBBD). Date of surgery was day 0. Evaluated patients received repeated SIACI bevacizumab (15 mg/kg) with BBBD at days 30 ± 7, 120 ± 7, and 210 ± 7 along with 6 weeks of standard chemoradiation. Response assessment in neur...
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#1Aldrich Kd (BCM: Baylor College of Medicine)
#2Vincent E. Horne (BCM: Baylor College of Medicine)
Last. Austin L. Brown (BCM: Baylor College of Medicine)H-Index: 7
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Background null Endocrine deficiencies are common following Craniospinal irradiation (CSI) in children with brain tumors, but empirical data comparing outcomes following proton (PRT) and photon radiation therapy (XRT) are limited. null Methods null This retrospective chart review compared the incidence of hypothyroidism, Growth hormone deficiency (GHD), and Adrenal insufficiency (AI) in patients with medulloblastoma treated with XRT and PRT between 1997 and 2016. All patients received CSI and ha...
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#1Jonas Ort (RWTH Aachen University)H-Index: 1
#2Hussam A. Hamou (RWTH Aachen University)H-Index: 3
Last. Hans Clusmann (RWTH Aachen University)H-Index: 20
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PET using radiolabeled amino acid [18F]-fluoro-ethyl-L-tyrosine (FET-PET) is a well-established imaging modality for glioma diagnostics. The biological tumor volume (BTV) as depicted by FET-PET often differs in volume and location from tumor volume of contrast enhancement (CE) in MRI. Our aim was to investigate whether a gross total resection of BTVs defined as < 1 cm3 of residual BTV (PET GTR) correlates with better oncological outcome. We retrospectively analyzed imaging and survival data from...
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The purpose of this review is to summarize recent updates regarding immune checkpoint inhibitor therapy in GBM patients including updates in brain immunology, clinical trials, mechanisms of resistance, and biomarkers of response. PubMed was searched to identify recent relevant articles on immune checkpoint inhibitor therapy as it pertains to GBM. Clinicaltrials.gov was also searched to identify relevant clinical trials. The reported randomized phase 2 and 3 clinical trials of immune checkpoint i...
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#1Shengyu Fang (Capital Medical University)H-Index: 4
#2Yuchao Liang (Capital Medical University)H-Index: 2
Last. Tao Jiang (Peking Union Medical College)
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Many patients with glioma experience surgery-related language impairment. This study developed a classification system to predict postoperative language prognosis. Sixty-eight patients were retrospectively reviewed. Based on their location, tumors were subtyped as follows: (I) inferior frontal lobe or precentral gyrus; (II) posterior central gyrus or supramarginal gyrus (above the lateral fissure level); (III) posterior region of the superior or middle temporal gyri or supramarginal gyrus (below...
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#1Débora Cabral de Carvalho Corrêa (UNIFESP: Federal University of São Paulo)H-Index: 1
#2Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 23
view all 10 authors...
Ependymoma (EPN) accounts for approximately 10% of all primary central nervous system (CNS) tumors in children and in most cases, chemotherapy is ineffective and treatment remains challenging. We investigated molecular alterations, with a potential prognostic marker and therapeutic target in EPNs of childhood and adolescence, using a next-generation sequencing (NGS) panel specific for pediatric neoplasms. We selected 61 samples with initial diagnosis of EPN from patients treated at Pediatric Onc...
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