Randomized Placebo‐Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy

Published on Feb 1, 2020in Annals of Neurology9.037
· DOI :10.1002/ANA.25655
Divyanshu Dubey22
Estimated H-index: 22
(Mayo Clinic),
Jeffrey W. Britton37
Estimated H-index: 37
(Mayo Clinic)
+ 11 AuthorsSean J. Pittock79
Estimated H-index: 79
(Mayo Clinic)
Objective Drug‐resistant seizures are common in patients with leucine‐rich, glioma‐inactivated 1 (LGI1)‐IgG associated and contactin‐associated protein‐like 2 (CASPR2)‐IgG associated encephalitis. We performed the first randomized double‐blind placebo‐controlled trial to evaluate efficacy of intravenous immunoglobulin (IVIG) in reducing seizure frequency.
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