OBJECTIVE On behalf of the German Neurological Society (DGN), a study was conducted into how far former chairmen, honorary chairmen, and honorary members could be regarded as incriminated from the National Socialist period. While an online supplement of this journal presents seven individual biographies (in six papers) by way of example, this paper offers an overview summarizing the project results and introducing the biographies. METHODS The first part and the methodological section discuss the...
OBJECTIVE Friedreich ataxia (FRDA) is an inherited neurological disease defined by progressive movement incoordination. We undertook a comprehensive characterisation of the spatial profile and progressive evolution of structural brain abnormalities in people with FRDA. METHODS A coordinated international analysis of regional brain volume using magnetic resonance imaging data charted the whole-brain profile, inter-individual variability, and temporal staging of structural brain differences in 248...
#2Ting Guo(U of T: University of Toronto)H-Index: 12
Last. Steven P. Miller(U of T: University of Toronto)H-Index: 77
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OBJECTIVE To determine how preterm white matter injury (WMI) and long-term thalamic growth interact to predict eight-year neurodevelopmental outcomes. METHODS A prospective cohort of 114 children born at 24-32 weeks' gestational age (GA) underwent structural and diffusion tensor magnetic resonance imaging early in life (median 32 weeks), at term-equivalent age and at eight years. Manual segmentation of neonatal WMI was performed on T1-weighted images and thalamic volumes were obtained using the ...
Last. Takayuki Kondo(Kansai Medical University)H-Index: 21
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Objective null Although plasmapheresis is a treatment option for patients with autoimmune neurological diseases, treatment response varies greatly among patients. The main objective of this study was to find out if biological/immune traits correlate with a beneficial response. null Methods null We thoroughly analyzed immune phenotypes in paired blood samples from a cohort of 31 patients with multiple sclerosis before and after plasmapheresis, in parallel with clinical evaluation of treatment res...
#1Simon Pan(UCSF: University of California, San Francisco)H-Index: 5
#2Jonah R. Chan(UCSF: University of California, San Francisco)H-Index: 48
Central nervous system demyelination in multiple sclerosis (MS) and subsequent axonal degeneration represents a major cause of clinical morbidity. Learning, salient experiences, and stimulation of neuronal activity induce new myelin formation in rodents and in animal models of demyelination, remyelination can be enhanced by via experience- and activity-dependent mechanisms. Furthermore, preliminary studies in MS patients supports the use of neuromodulation and rehabilitation exercises for sympto...
Last. Renaud Du Pasquier(CHUV: University Hospital of Lausanne)H-Index: 35
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Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by JC virus (JCV), which occurs in immunocompromised individuals. Management of PML relies on restoration of immunity within the CNS. However, when this restoration cannot be readily achieved PML has a grim prognosis. Innovative strategies have shown promises in promoting anti-JCV immune responses, and include T cell adoptive transfer or immune checkpoint inhibitor therapies. Conver...
Objective null S. pneumoniae is the most common cause of bacterial meningitis, a disease that, despite treatment with antibiotics, still is associated with a high mortality and morbidity worldwide. Diffuse brain swelling is a leading cause of morbidity in S. pneumoniae meningitis. We hypothesized that neutrophil extracellular traps (NETs) disrupt CSF transport by the glymphatic system and contribute to edema formation in S. pneumoniae meningitis. null Methods null We used DNase I treatment to di...
#1Hadar Kolb(NIH: National Institutes of Health)H-Index: 2
#2M. Absinta(UniSR: Vita-Salute San Raffaele University)H-Index: 5
Last. Daniel S. Reich(NIH: National Institutes of Health)H-Index: 63
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OBJECTIVE To noninvasively assess myelin status in chronic white matter lesions of multiple sclerosis (MS), we developed and evaluated a simple classification scheme based on T1 relaxation time maps derived from 7-tesla postmortem and in vivo MRI. METHODS Using the MP2RAGE MRI sequence, we classified 36 lesions from 4 postmortem MS brains as "long-T1," "short-T1," and "mixed-T1" by visual comparison to neocortex. Within these groups, we compared T1 times to histologically derived measures of mye...
OBJECTIVE The subthalamic nucleus (STN) and internal globus pallidus (GPi) are the most effective targets in deep brain stimulation (DBS) for Parkinson's disease (PD). However, the common and specific effects on brain connectivity of stimulating the two nuclei remain unclear. METHODS Patients with PD receiving STN-DBS (n=27, six women, mean age 64.8 years) or GPi-DBS (n=28, thirteen women, mean age 64.6 years) were recruited for resting-state functional magnetic resonance imaging to assess the e...