Approach Combining Dosimetry and Biology to Predict Severe Toxicity of Radiotherapy for Head and Neck Squamous Cell Carcinomas

Radiotherapy (RT) used alone or added to surgery in head and neck squamous cell carcinomas (HNSCC) leads to severe acute toxicity in up 30-40% patients (pts). Recent studies have stressed the role of the nucleoshuttling of the phosphorylated form of the ATM protein (pATM) in the response to radiation, and the discrimination power of this molecular endpoint in predicting individual radiosensitivity. Furthermore, a predictive assay based on the...