Tiziana Rancati
University of Milan
CancerInternal medicineRadiologyUrologySurgeryOncologyProspective cohort studyCohort studyProstateProstate cancerRectumPopulationToxicityNuclear medicineIn patientRadiation therapyBreast cancerMedicineCohortUrinary systemGastroenterology
306Publications
27H-index
2,540Citations
Publications 303
Newest
#1Rossana IngargiolaH-Index: 3
#2Alessandro VaiH-Index: 4
Last. Barbara VischioniH-Index: 14
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#1Fernando Munoz (AUSL: Academy for Urban School Leadership)H-Index: 11
#2Giuseppe SanguinetiH-Index: 37
Last. A. FaiellaH-Index: 5
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Background: Baseline urinary incontinence (UI) strongly modulates UI recovery after adjuvant/salvage radiotherapy (ART/SRT), inducing clinicians to postpone it “as much as possible”, maximizing UI recovery but possibly reducing efficacy. This series aims to analyze the trend of UI recovery and its predictors at radiotherapy start. Methods: A population of 408 patients treated with ART/SRT enrolled in a cohort study (ClinicalTrials.gov #NCT02803086) aimed at developing predictive models of radiat...
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#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
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We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heter...
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#1Martin A. Ebert (SCGH: Sir Charles Gairdner Hospital)H-Index: 26
#2Sarah L. Gulliford (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 23
Last. Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
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For decades, dose-volume information for segmented anatomy has provided the essential data for correlating radiotherapy dosimetry with treatment-induced complications. Dose-volume information has formed the basis for modelling those associations via normal tissue complication (NTCP) models and for driving treatment planning. Limitations to this approach have been identified. Many studies have emerged demonstrating that the incorporation of information describing the spatial nature of the dose di...
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#1Paolo GandelliniH-Index: 25
Last. Nadia ZaffaroniH-Index: 66
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Active surveillance (AS) has evolved as a strategy alternative to radical treatments for very low risk and low-risk prostate cancer (PCa). However, current criteria for selecting AS patients are still suboptimal. Here, we performed an unprecedented analysis of the circulating miRNome to investigate whether specific miRNAs associated with disease reclassification can provide risk refinement to standard clinicopathological features for improving patient selection. The global miRNA expression profi...
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#1Nicola Rares Franco (Ghent University Hospital)
#1Nicola Rares Franco (Ghent University Hospital)H-Index: 1
Last. Tiziana RancatiH-Index: 27
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AIM To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 li...
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#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
Last. Matteo MorettiH-Index: 31
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Ionizing radiation (IR) is used in radiotherapy as a treatment to destroy cancer. Such treatment also affects other tissues, resulting in the so-called normal tissue complications. Endothelial cells (ECs) composing the microvasculature have essential roles in the microenvironment’s homeostasis (ME). Thus, detrimental effects induced by irradiation on ECs can influence both the tumor and healthy tissue. In-vitro models can be advantageous to study these phenomena. In this systematic review, we an...
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#1Andrea BresolinH-Index: 1
#2A. FaiellaH-Index: 5
Last. Cesare CozzariniH-Index: 43
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Abstract Background and purpose To assess bowel dose-volume relationships for acute patient-reported intestinal symptoms of patients treated with whole-pelvis intensity-modulated radiotherapy (WPRT) for prostate cancer. Materials and methods Complete data of 415 patients enrolled in a multi institute, prospective trial (#NCT02803086) treated with radical (31%), adjuvant (33%) and salvage (36%) intent at a median dose to pelvic nodes/lymph-nodal area of 53Gy were available. The most severe change...
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#1Paolo GandelliniH-Index: 25
#2Nicola Casiraghi (University of Trento)H-Index: 7
Last. Nadia ZaffaroniH-Index: 66
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#1Paola DordoniH-Index: 6
#1Paola DordoniH-Index: 2
Last. Lara BellarditaH-Index: 10
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OBJECTIVE: To investigate whether prostate cancer (PCa) patients' coping strategies (i.e., fighting spirit, anxious preoccupation, fatalism, helplessness/hopelessness, and avoidance) significantly change during the first 3-year follow-up period of active surveillance (AS). MATERIALS AND METHODS: Altogether, 104 patients on AS completed the Mini-Mental Adjustment to Cancer (Mini-MAC) at baseline (T0), at 10 and 12 months after diagnostic biopsy (T1 and T2, respectively) and then at 24- (T3) and 3...
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