Sandrine Pereira
French Institute of Health and Medical Research
Internal medicineDNA repairPathologyDNA damageOncologyMolecular biologyAndrologyChemistryApoptosisEmbryoRadiosensitivityOxidative stressZebrafishEpilepsyGenotoxicityComet assayDanioToxicityMathematicsMicronucleus testCancer researchRadiation therapyGeneticsBiochemistryMedicineBiologyCell biology
43Publications
23H-index
1,910Citations
Publications 41
Newest
#1Sophie DeneuveH-Index: 7
#2Céline MirjoletH-Index: 12
Last. Sandrine PereiraH-Index: 23
view all 11 authors...
Radiation therapy (RT), either alone or in combination with surgery and/or chemotherapy is a keystone of cancers treatment. Early toxicity is common, sometimes leading to discontinuation of treatment. Recent studies stressed the role of the phosphorylated ATM (pATM) protein in RT-toxicity genesis and its ability in predicting individual radiosensitivity (IRS) in fibroblasts. Here we assessed the reliability of the pATM quantification in lymphocytes to predict IRS. A first retrospective study was...
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#1Mélanie L. Ferlazzo (French Institute of Health and Medical Research)H-Index: 7
#2Elise Berthel (French Institute of Health and Medical Research)H-Index: 5
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 11 authors...
AbstractPurpose: Xeroderma Pigmentosum (XP) is a rare, recessive genetic disease associated with photosensitivity, skin cancer proneness, neurological abnormalities and impaired nucleotide excision...
3 CitationsSource
Purpose/Objective(s): Radiotherapy (RT) used alone or added to surgery in head and neck squamous cell carcinomas (HNSCC) leads to severe acute toxicity in up 30-40% patients (pts). Recent studies have stressed the role of the nucleoshuttling of the phosphorylated form of the ATM protein (pATM) in the response to radiation, and the discrimination power of this molecular endpoint in predicting individual radiosensitivity. Furthermore, a predictive assay based on the quantification of the pATM by E...
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Purpose: The challenge of optimizing patient care around radiation therapy is constantly tackled with a flow of innovations (Robot assisted surgery, Protons, Spacer, etc.). Plethoras of studies demonstrated efficacy of new techniques and solutions, but still very few discriminate patients on their likelihood to encounter side effects. Radiosensitivity tests would be key in decision making in different cases: radiation vs surgery, hypo vs normofractionnated, proton vs photontherapy, and implement...
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#1Olivier Simon (Institut de radioprotection et de sûreté nucléaire)H-Index: 13
#2I. Barjhoux (Institut de radioprotection et de sûreté nucléaire)
Last. Christelle Adam-Guillermin (Institut de radioprotection et de sûreté nucléaire)H-Index: 20
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Abstract Zebrafish were chronically exposed to Am-241, an alpha-emitting radionuclide via daily consumption of an enriched artificial diet. Am-241 uptake was quantified in Danio rerio after 5 and 21 days of exposure via daily Am-spiked food ingestion and after 21 days of exposure followed by 5 days of depuration. Americium accumulates mostly in digestive tract, muscle, rest of the body but the accumulation levels and trophic transfer rate (0.033–0.013%) were low. Corresponding cumulative doses w...
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#1Guillaume Vogin (CNRS: Centre national de la recherche scientifique)H-Index: 14
#2Thierry Bastogne (University of Lorraine)H-Index: 17
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 7 authors...
Purpose The ability to identify, before treatment, those patients who will overreact to radiation therapy would have sound positive clinical implications. By focusing on DNA double-strand breaks recognition and repair proteins after irradiation, we recently demonstrated that the maximal number of phosphorylated ATM (pATM) nuclear foci in the first hour (pATMmax) after ex vivo irradiation correlated with postradiation therapy toxicity severity. We performed additional analyses of our whole collec...
16 CitationsSource
3 CitationsSource
#1Sophie DeneuveH-Index: 7
#2Céline MirjoletH-Index: 12
Last. Sandrine PereiraH-Index: 23
view all 6 authors...
Purpose or Objective The societal and clinical impact of post-radiotherapy Adverse Events (AE) have highlighted the need of molecular and cellular parameters that can predict the outcome of the treatment. Recent studies have stressed the role of the nucleoshuttling of the ATM protein in the response to radiation, and the statistical performances of this molecular endpoint to predict individual radiosensitivity. The purpose of this study was to develop a predictive assay based on the quantificati...
Purpose or Objective The societal and clinical impact of post-radiotherapy Adverse Events (AE) have highlighted the need of molecular and cellular parameters that can predict the outcome of the treatment. Recent studies have stressed the role of the nucleoshuttling of the ATM protein in the response to radiation, and the statistical performances of this molecular endpoint to predict individual radiosensitivity. The purpose of this study was to develop a predictive assay based on the quantificati...
Source
#1Sandrine Pereira (French Institute of Health and Medical Research)H-Index: 23
#2Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 10 authors...
Purpose To examine the possibility of predicting clinical radiosensitivity by quantifying the nuclear forms of autophosphorylated ATM protein (pATM) via a specific enzyme-linked immunosorbent assay (ELISA). Methods and Materials This study was performed on 30 skin fibroblasts from 9 radioresistant patients and 21 patients with adverse tissue reaction events. Patients were divided into 2 groups: radioresistant (toxicity grade Results The pATM ELISA data were in quantitative agreement with the imm...
23 CitationsSource